CAJ | 학술논문

目的：分析我国HIV-1基因型的分布及变化趋势。方法计算机检索中国医院知识总库（CHKD，1994-）、万方数据资源系统（1998-）、中国生物医学文献数据库（CBMDisc）以及PubMed数据库，并结合文献追溯的方法，收集我国HIV-1基因分型的相关文献，提取符合标准的文献信息，对相同的HIV-1亚型分别按地区、研究时间、研究人群分组，并进行数量合并，计算百分比。结果共纳入175篇文献，包含285条记录。我国HIV-1流行最广泛的毒株为CRF01_AE、CRF07_BC重组型，以及B’亚型，但不同地区基因亚型存在差异。北方地区流行毒株比较单一，且流行较稳定。南方地区HIV-1毒株的亚型分布较为复杂，存在多种亚型及流行重组型，同时存在一定比例新的独特重组亚型流行。我国早期HIV-1以B’及C亚型流行为主，近年来，尤其是2007年以后，CRF01_AE重组型逐渐增高，成为我国优势毒株，同时存在一定比例的CRF07_BC、CRF08_BC重组型和B’亚型流行。结论我国HIV-1基因型地区分布、人群分布差异较大，且随着时间的推移，基因型分布产生较大的变化，流行更为复杂。
목적：분석아국HIV-1기인형적분포급변화추세。방법계산궤검색중국의원지식총고（CHKD，1994-）、만방수거자원계통（1998-）、중국생물의학문헌수거고（CBMDisc）이급PubMed수거고，병결합문헌추소적방법，수집아국HIV-1기인분형적상관문헌，제취부합표준적문헌신식，대상동적HIV-1아형분별안지구、연구시간、연구인군분조，병진행수량합병，계산백분비。결과공납입175편문헌，포함285조기록。아국HIV-1류행최엄범적독주위CRF01_AE、CRF07_BC중조형，이급B’아형，단불동지구기인아형존재차이。북방지구류행독주비교단일，차류행교은정。남방지구HIV-1독주적아형분포교위복잡，존재다충아형급류행중조형，동시존재일정비례신적독특중조아형류행。아국조기HIV-1이B’급C아형류행위주，근년래，우기시2007년이후，CRF01_AE중조형축점증고，성위아국우세독주，동시존재일정비례적CRF07_BC、CRF08_BC중조형화B’아형류행。결론아국HIV-1기인형지구분포、인군분포차이교대，차수착시간적추이，기인형분포산생교대적변화，류행경위복잡。
Objective To provide information on the geographical distribution of HIV-1 genotypes and subtypes in the population of China. Methods A comprehensive search was carried out in China Hospital Knowledge Database(CHKD),Wanfang(Chinese),CBMDisc and PubMed databases to identify all studies published related to HIV-1 genotypes in China. All studies were grouped according to the sites,period and objects for analyzing the distribution of HIV genotypes. Results A total of 175 studies were included in this Meta-analysis,which contained 285 records. We found that the predominate genotypes in China were B’ subtype,CRF01_AE,CRF07_BC and CRF08_BC,but the subtype distribution of HIV-1 was different in the western and southern parts of the country. CRF01_AE had a significant increase while subtype B’ showed a decrease. There were various HIV-1 subtypes among individuals who acquired HIV through sexual contacts and CRF01_AE was most commonly identified in this group of people. Conclusion The distribution of HIV-1 genotypes in Chinese people significantly changed,together with high complexity of the HIV-1 epidemics noticed in China.