CAJ | 학술논문

目的：研究白介素6（IL-6）、内皮素1（ET-1）及E选择素（E-selectin）与心脑血管事件发生的关系。方法在对2589名蒙古族人群连续随访10年的队列研究基础上，采用巢式病例对照研究方法，分析IL-6、ET-1和E-selectin与心脑血管事件发生的关系，利用logistic回归分析方法计算OR值及其95%CI。结果病例组与对照组的IL-6（7.66 vs.8.77 pg/ml）、ET-1（0.74 vs.0.75 pg/ml）和E-selectin（17.96 vs.18.32 ng/ml）的差异无统计学意义（P＞0.05）。logistic分析表明，与IL-6≤23.91 pg/ml或ET-1≤1.33 pg/ml或E-selectin≤24.43 ng/ml者相比，IL-6＞23.91 pg/ml或ET-1＞1.33 pg/ml或E-selectin＞24.43 ng/ml者发生心脑血管事件的多因素调整后的OR值及其95%CI分别为0.69（0.41～1.16）、1.10（0.66～1.85）和1.19（0.71～2.00），差异均无统计学意义（P＞0.05）。结论调查人群中基线IL-6、ET-1及E-selectin水平与心血管事件危险性无显著关联。
목적：연구백개소6（IL-6）、내피소1（ET-1）급E선택소（E-selectin）여심뇌혈관사건발생적관계。방법재대2589명몽고족인군련속수방10년적대렬연구기출상，채용소식병례대조연구방법，분석IL-6、ET-1화E-selectin여심뇌혈관사건발생적관계，이용logistic회귀분석방법계산OR치급기95%CI。결과병례조여대조조적IL-6（7.66 vs.8.77 pg/ml）、ET-1（0.74 vs.0.75 pg/ml）화E-selectin（17.96 vs.18.32 ng/ml）적차이무통계학의의（P＞0.05）。logistic분석표명，여IL-6≤23.91 pg/ml혹ET-1≤1.33 pg/ml혹E-selectin≤24.43 ng/ml자상비，IL-6＞23.91 pg/ml혹ET-1＞1.33 pg/ml혹E-selectin＞24.43 ng/ml자발생심뇌혈관사건적다인소조정후적OR치급기95%CI분별위0.69（0.41～1.16）、1.10（0.66～1.85）화1.19（0.71～2.00），차이균무통계학의의（P＞0.05）。결론조사인군중기선IL-6、ET-1급E-selectin수평여심혈관사건위험성무현저관련。
Objective To investigate the relationship between interleukin-6(IL-6),endothelin-1 (ET-1),E-selectin and the risk of cardio-cerebrovascular events. Methods Based on a cohort study in which 2 589 Mongolians had been followed up for 10 years,a nested case-control study was carried out to analyze the relationship between IL-6, ET-1, E-selectin and the risk of cardio-cerebrovascular events. Logistic regression analysis was used to calculate the odds ratio(OR) and 95%confidence intervals(95%CI). Results The average level of IL-6(7.66 vs. 8.77 pg/ml), ET-1(0.74 vs. 0.75 pg/ml) and E-selectin (17.96 vs. 18.32 ng/ml) were not significantly different between the case and the control groups(P>0.05). Data from the logistic regression analysis showed that IL-6,ET-1 and E-selectin were not significantly associated with the risk of cardio-cerebrovascular events. The multivariable adjusted ORs(95%CI)on the risk of cardio-cerebrovascular events were 0.69 (0.41-1.16),1.10 (0.66-1.85) and 1.19(0.71-2.00) for the participants with IL-6>23.91 pg/ml ,ET-1>1.33 pg/ml and E-selectin>24.43 ng/ml,respectively,compared with those having IL-6≤23.91 pg/ml ,ET-1≤1.33 pg/ml or E-selectin≤24.43 ng/ml. Conclusion Data from our study indicated that the levels of IL-6,ET-1 and E-selectin at baseline were not significantly associated with the risk of cardio-cerebrovascular events in people from Inner Mongolia.