CAJ | 학술논문

目的：分析和探讨江西省H10N8禽流感病毒感染患者的感染来源。方法采用江西省2013年底及2014年年初报告的H10N8禽流感病毒感染患者的流行病学个案调查资料和相关标本检测结果进行描述性流行病学分析。结果3例H10N8感染患者均由重症肺炎监测发现，其中2例死亡，1例病程超过6个月；发病前均有活禽或活禽市场暴露史；3例患者的含漱液或下呼吸道抽吸液标本经南昌市及江西省疾病预防控制中心检测，结果显示为甲型流感2009pdmH1、H3、H5、H7、H9等亚型阴性，患者1和患者2的标本为甲型流感通用引物阳性，患者3的标本为H10阳性。3份标本经国家流感中心进行检测，结果显示为H10N8阳性。33名密切接触者在1周的观察期内未出现流感样症状；患者暴露活禽市场环境监测标本中H10N8禽流感病毒RT-PCR检测阳性率为5.19%；落实各项防控措施后，无新发患者。结论江西省3例H10N8禽流感病毒感染患者可能与暴露于活禽市场有关。
목적：분석화탐토강서성H10N8금류감병독감염환자적감염래원。방법채용강서성2013년저급2014년년초보고적H10N8금류감병독감염환자적류행병학개안조사자료화상관표본검측결과진행묘술성류행병학분석。결과3례H10N8감염환자균유중증폐염감측발현，기중2례사망，1례병정초과6개월；발병전균유활금혹활금시장폭로사；3례환자적함수액혹하호흡도추흡액표본경남창시급강서성질병예방공제중심검측，결과현시위갑형류감2009pdmH1、H3、H5、H7、H9등아형음성，환자1화환자2적표본위갑형류감통용인물양성，환자3적표본위H10양성。3빈표본경국가류감중심진행검측，결과현시위H10N8양성。33명밀절접촉자재1주적관찰기내미출현류감양증상；환자폭로활금시장배경감측표본중H10N8금류감병독RT-PCR검측양성솔위5.19%；락실각항방공조시후，무신발환자。결론강서성3례H10N8금류감병독감염환자가능여폭로우활금시장유관。
Objective To analyze and discuss the source and epidemic disposition of human infection with avian influenza A(H10N8)virus. Methods Epidemiological surveys were used to collect related data and RT-PCR was applied to detect the specimens collected from cases,close contacts related exposure to live poultry markets. Data were analyzed descriptively. Results Three cases were discovered by surveillance on patients with severe pneumonia,two of the three died,but one in the hospital with the course over 6 months. All the three cases had histories of exposure to live poultry or related markets. Lower respiratory tract gargle aspirate samples of 3 patients were detected by Nanchang Municipal Center for Disease Control and Prevention (CDC) and Jiangxi Provincial CDC,and the results showed the influenza 2009pdmH1,H3,H5,H7,H9 subtypes negative. Specimen of patient 1 and 2 was positive for influenza A universal primers. Specimen of patient 3 was positive for H10N8 detected by Chinese National Influenza Center. All 33 close contacts of the patients were negative for H10N8 virus. Positive rate of the total poultry environmental specimens collected from the cases exposure markets was 5.19%. No new cases were found,after the prevention and control messages were implemented. Conclusion Three cases of H10N8 avian influenza virus infection province might be associated with exposure to live poultry market in Jiangxi.