CAJ | 학술논문

目的：了解山东省胶州市暗娼HIV、梅毒、Ⅱ型单纯疱疹病毒（HSV-2）感染状况以及相关影响因素。方法采用方便抽样法招募山东省胶州市暗娼人群，通过匿名现场问卷调查收集相关信息，采集血样进行HIV、梅毒和HSV-2检测，并以梅毒螺旋体ELISA检测与HSV-2抗体ELISA检测均为阳性定义为双重感染。结果共调查460名暗娼，其中HIV感染率为0.22%，梅毒感染率为5.9%，HSV-2感染率为43.0%，梅毒/HSV-2双重感染率为11.7%。22.8%的暗娼承认吸食过新型毒品，吸食新型毒品暗娼的梅毒感染率为12.4%，HSV-2感染率为55.2%，梅毒/HSV-2双重感染率为22.9%。多因素分析显示：梅毒感染的危险因素有吸食新型毒品（OR＝3.61，95%CI：1.62～8.06）、第一次商业性行为年龄＞20岁（OR＝2.80，95%CI：1.15～6.85）、最近1个月性服务场所数≥2个（OR＝4.37，95%CI：0.83～22.83）；而HSV-2感染的危险因素为吸食新型毒品（OR＝2.30，95%CI：1.43～3.70）、来自低档场所（OR＝2.61，95%CI：1.66～4.10）、在本地工作≥1年（OR＝2.01，95%CI：1.28～3.14）、第一次商业性行为年龄＞20岁（OR＝1.77，95%CI：1.16～2.69）、文化程度为文盲或小学（OR＝2.27，95%CI：1.18～4.36）；梅毒/HSV-2双重感染的危险因素有吸食新型毒品（OR＝3.95，95%CI：2.09～7.44）、文化程度为文盲或小学（OR＝2.43，95%CI：1.10～5.36）、年龄为21～30岁（OR＝2.95，95%CI：1.08～8.03）和≥31岁（OR＝7.05，95%CI：2.48～20.01）。结论胶州市暗娼梅毒、HSV-2及其重复感染率较高，特别是吸食新型毒品暗娼，应针对感染人群、吸毒人群进行有效的健康教育和行为干预。
목적：료해산동성효주시암창HIV、매독、Ⅱ형단순포진병독（HSV-2）감염상황이급상관영향인소。방법채용방편추양법초모산동성효주시암창인군，통과닉명현장문권조사수집상관신식，채집혈양진행HIV、매독화HSV-2검측，병이매독라선체ELISA검측여HSV-2항체ELISA검측균위양성정의위쌍중감염。결과공조사460명암창，기중HIV감염솔위0.22%，매독감염솔위5.9%，HSV-2감염솔위43.0%，매독/HSV-2쌍중감염솔위11.7%。22.8%적암창승인흡식과신형독품，흡식신형독품암창적매독감염솔위12.4%，HSV-2감염솔위55.2%，매독/HSV-2쌍중감염솔위22.9%。다인소분석현시：매독감염적위험인소유흡식신형독품（OR＝3.61，95%CI：1.62～8.06）、제일차상업성행위년령＞20세（OR＝2.80，95%CI：1.15～6.85）、최근1개월성복무장소수≥2개（OR＝4.37，95%CI：0.83～22.83）；이HSV-2감염적위험인소위흡식신형독품（OR＝2.30，95%CI：1.43～3.70）、래자저당장소（OR＝2.61，95%CI：1.66～4.10）、재본지공작≥1년（OR＝2.01，95%CI：1.28～3.14）、제일차상업성행위년령＞20세（OR＝1.77，95%CI：1.16～2.69）、문화정도위문맹혹소학（OR＝2.27，95%CI：1.18～4.36）；매독/HSV-2쌍중감염적위험인소유흡식신형독품（OR＝3.95，95%CI：2.09～7.44）、문화정도위문맹혹소학（OR＝2.43，95%CI：1.10～5.36）、년령위21～30세（OR＝2.95，95%CI：1.08～8.03）화≥31세（OR＝7.05，95%CI：2.48～20.01）。결론효주시암창매독、HSV-2급기중복감염솔교고，특별시흡식신형독품암창，응침대감염인군、흡독인군진행유효적건강교육화행위간예。
Objective To analyze the prevalence rates and associated risk factors on HIV, syphilis,herpes simplex virus-2(HSV-2)among female sex workers(FSWs)in Jiaozhou,Shandong province. Methods Through convenient sampling,an anonymous questionnaire survey was conducted on female sex workers to collect related information. Blood specimens were drawn for serological tests on HIV,syphilis and HSV-2 antibodies,respectively. Patients with positive results from both treponema pallidum and HSV-2 tested by ELISA method,were defined as being superinfected. Results A total of 460 FSWs were recruited in this study. The prevalence rates of HIV,syphilis,HSV-2,and syphilis/HSV-2 superinfection were 0.22%,5.9%,43.0%,and 11.7%, respectively. Among the methamphetamine users,the prevalence rates of syphilis,HSV-2,and syphilis/HSV-2 superinfection were 12.4%,55.2%,and 22.9%,respectively. Results from multivariate analysis showed that factors that significantly associated with syphilis infection would include:methamphetamine use(OR=3.61,95%CI:1.62-8.06),having first commercial sex intercourse at under 20 years of age(OR=2.80,95% CI:1.15-6.85),more than 2 establishments that the FSWs worked in the last month(OR=4.37,95%CI:0.83-22.83). Factors associated with HSV-2 infection were methamphetamine use(OR=2.30,95%CI:1.43-3.70),having first commercial sex intercourse at under 20 years of age (OR=1.77,95%CI:1.16-2.69),working at low-end establishments (OR=2.61,95%CI:1.66-4.10),working at the local sex-work venues for more than one year(OR=2.01,95%CI:1.28-3.14),with low education backgrounds(OR=2.27,95%CI:1.18-4.36),using methamphetamine(OR=3.95,95%CI:2.09-7.44),low education background(OR=2.43,95%CI:1.10-5.36),21-30 year-olds(OR=2.95,95%CI:1.08-8.03),older than 31 years of age(OR=7.05, 95%CI:2.48-20.01) etc.,were independent risk factors associated with the superinfection of syphilis and HSV-2. Conclusion The prevalence rates of syphilis,HSV-2 and syphilis/HSV-2 superinfection were relatively high among FSWs in Jiaozhou,especially among the FSWs who were methamphetamine users.