CAJ | 학술논문

通过荧光定量PCR检测不同分期慢性粒细胞白血病(CML)患者骨髓中PTEN、BMI-1、BCR-ABL的表达量，分析Sokal分期与基因表达的相关性。结果显示按照Sokal分期分为高危组、中危组及低危组， BMI-1、PTEN、BCR-ABL3个基因的表达水平在3组间比较差异无统计学意义。表明CML患者预后相关基因表达与Sokal分期之间无相关性。
통과형광정량PCR검측불동분기만성립세포백혈병(CML)환자골수중PTEN、BMI-1、BCR-ABL적표체량，분석Sokal분기여기인표체적상관성。결과현시안조Sokal분기분위고위조、중위조급저위조， BMI-1、PTEN、BCR-ABL3개기인적표체수평재3조간비교차이무통계학의의。표명CML환자예후상관기인표체여Sokal분기지간무상관성。
To use the real-time PCR to detect the expression of PTEN,BMI-1,BCR-ABL of 73 cases chronic mye-loid leukemia in different stages,and analyze the dependency between the staging and expression. Results showed the expression of BMI-1,PTEN,BCR-ABL in different stages following Sokal is no statistical significance with stage. It indicates that there is no statistical significance between the expression of PTEN,BMI-1,BCR-ABL and Sokal stage.