CAJ | 학술논문

目的探讨母鼠孕期和哺乳期经水摄入双酚 A (BPA)对子代未成年期体重的影响。方法将妊娠的ICR母鼠随机分成 BPA 低、中、高剂量组(2.2829、22.8290、228.2900μg/L)、空白对照组和溶剂对照组；母鼠自妊娠第0天(GD 0)至仔鼠出生后第21天( PND 21)经饮水暴露BPA,孕期每3 d记录1次母鼠体重,仔鼠体重在哺乳期每3 d记录1次,断乳后至PND 42期间每周记录1次。结果各BPA暴露组母鼠孕期体重、窝平均仔鼠数及断乳前仔鼠平均体重与对照组相比差异均无统计学意义；PND 42时BPA高剂量组仔鼠体重与对照组相比显著增加(P<0.05)；PND 28~PND 42时各组雌性仔鼠体重均无明显差异；PND 35时中、高剂量组及PND 42时BPA各组雄性仔鼠体重与对照组相比均显著增加(P<0.05,P<0.01),以PND 42时高剂量组增加更为显著。结论母鼠孕期及哺乳期暴露较低剂量BPA对子代未成年期的体重有一定影响,而且对雄性子代影响更明显。
목적탐토모서잉기화포유기경수섭입쌍분 A (BPA)대자대미성년기체중적영향。방법장임신적ICR모서수궤분성 BPA 저、중、고제량조(2.2829、22.8290、228.2900μg/L)、공백대조조화용제대조조；모서자임신제0천(GD 0)지자서출생후제21천( PND 21)경음수폭로BPA,잉기매3 d기록1차모서체중,자서체중재포유기매3 d기록1차,단유후지PND 42기간매주기록1차。결과각BPA폭로조모서잉기체중、와평균자서수급단유전자서평균체중여대조조상비차이균무통계학의의；PND 42시BPA고제량조자서체중여대조조상비현저증가(P<0.05)；PND 28~PND 42시각조자성자서체중균무명현차이；PND 35시중、고제량조급PND 42시BPA각조웅성자서체중여대조조상비균현저증가(P<0.05,P<0.01),이PND 42시고제량조증가경위현저。결론모서잉기급포유기폭로교저제량BPA대자대미성년기적체중유일정영향,이차대웅성자대영향경명현。
Objective To investigate the effect of maternal exposure to bisphenol A(BPA) via drinking water on body weight of immature offspring during pregnancy and lactation. Methods The pregnant female ICR mice were exposed to BPA groups(2. 282 9,22. 829 0,228. 290 0 μg/L) by drinking water from gestational day(GD)0 till postnatal day (PND)21,water and dimethyl sulfoxide(0. 01%) were served as blank and vehicle control. Maternal body weight was recorded every three days during pregnancy. Weight of pups per litter was measured every three days during lactation. Body weight of offspring was taken notes every week till PND 42 after delactation. ResultsThere was no significant difference in pregnant maternal body weight, average numbers and body weight of pups per litter preweaning among all groups. The offspring weight of the high-dose group at PND 42 was increased compared with control groups(P<0.05). The weight of female offspring was not significantly different among all groups at PND 28~42. The male offspring weight of the middle/high group at PND 35 and all groups at PND 42 significantly was elevated(P<0.05,P<0.01),and the high group was most significant. Conclusion Body weight of immature offspring is affected,especially male offspring after delectation by pregnant and lactational BPA exposure.