CAJ | 학술논문

目的：探讨心力衰竭患者快速检测全血N末端B型脑钠肽前体（ NT-proBNP）的临床价值。方法：选取心内科收治的心力衰竭患者78例作为观察组，选取同期非心血管病患者15例作为对照组，入院0.5 h内用Nano-Checker710免疫层析检测仪完成床边快速测定全血NT-proBNP浓度。观察组患者出院后随访3个月，记录各组因不良心血管事件而再次住院或死亡的患者例数。结果：观察组按NYHA心功能分级，随着心功能分级逐渐加重，NT-proBNP含量呈明显上升趋势，与心力衰竭的严重程度呈正比。观察组患者出院后随访3个月，Ⅲ级组因不良心血管事件而再次住院2例，Ⅳ级组因不良心血管事件而再次住院6例、死亡2例。结论：全血NT-proBNP水平与心力衰竭的严重程度存在密切的关系，可作为反映心功能状态的良好的客观指标。床边快速检测全血NT-proBNP浓度可对心力衰竭做出及时准确的诊断性评估，并对近期预后判定具有一定的价值。
목적：탐토심력쇠갈환자쾌속검측전혈N말단B형뇌납태전체（ NT-proBNP）적림상개치。방법：선취심내과수치적심력쇠갈환자78례작위관찰조，선취동기비심혈관병환자15례작위대조조，입원0.5 h내용Nano-Checker710면역층석검측의완성상변쾌속측정전혈NT-proBNP농도。관찰조환자출원후수방3개월，기록각조인불양심혈관사건이재차주원혹사망적환자례수。결과：관찰조안NYHA심공능분급，수착심공능분급축점가중，NT-proBNP함량정명현상승추세，여심력쇠갈적엄중정도정정비。관찰조환자출원후수방3개월，Ⅲ급조인불양심혈관사건이재차주원2례，Ⅳ급조인불양심혈관사건이재차주원6례、사망2례。결론：전혈NT-proBNP수평여심력쇠갈적엄중정도존재밀절적관계，가작위반영심공능상태적량호적객관지표。상변쾌속검측전혈NT-proBNP농도가대심력쇠갈주출급시준학적진단성평고，병대근기예후판정구유일정적개치。
Objective To study the clinical value of rapid bedside detection of whole blood N-terminal B-type natriuretic peptide ( NT-proBNP)in patients with heart failure( HF). Methods Select 78 patients with heart failure admitted to Cardiology department of our hospital as the observation group,select 15 cases of non-cardiovascular disease in the same period as a control group,within 0. 5 h using Nano-Checker710 rapid determination of the detector completes the bedside NT-proBNP concentrations in whole blood. The patients were followed up 3 months after discharge,record the number of cases in each group due to adverse cardiovascular events hospitalized again or death . Results Observation group by NYHA class,with the cardiac function gradually worsened,NT-proBNP levels showed a clear up-ward trend,and is proportional to the severity of heart failure. The patients were followed up 3 months after discharge,III level group due to adverse cardiovascular events readmission two cases,IV level group due to adverse cardiovascular events and readmissions 6 cases,2 deaths. Conclusion There is a close relationship between cardiac function and NT-proBNP levels in whole blood . NT-proBNP levels can be used as a good reflection of objective indicators. Rapid bedside whole blood NT-proBNP concentrations in heart failure to make timely and accurate diagnostic evaluation,and also has a certain value on the recent prognosis.