CAJ | 학술논문

目的：通过对视网膜母细胞瘤（retinoblastoma，RB）患者实施眼动脉化疗，观察化疗效果及副反应。 　　方法：根据RB最新国际分期，对11例11眼A～D期RB患者，通过股动脉插管至眼动脉，使用马法兰（melphalan）经眼动脉灌注，对RB患者实施动脉化疗。 　　结果：所选患者共实施眼动脉灌注化疗23次，随访3～12mo，其中8例肿瘤明显缩小、钙化，2例病情进展，实施眼球摘除，1例失访。除部分患者术后短暂的恶心、呕吐、发热，没有出现死亡、中风、骨髓抑制等严重并发症。 　　结论：所选患者中，A、B、C期9例，7例有效，1例继续进展，1例失访，有效率88％；2例D期患者1例有效，1例继续进展，有效率50％。
목적：통과대시망막모세포류（retinoblastoma，RB）환자실시안동맥화료，관찰화료효과급부반응。 　　방법：근거RB최신국제분기，대11례11안A～D기RB환자，통과고동맥삽관지안동맥，사용마법란（melphalan）경안동맥관주，대RB환자실시동맥화료。 　　결과：소선환자공실시안동맥관주화료23차，수방3～12mo，기중8례종류명현축소、개화，2례병정진전，실시안구적제，1례실방。제부분환자술후단잠적악심、구토、발열，몰유출현사망、중풍、골수억제등엄중병발증。 　　결론：소선환자중，A、B、C기9례，7례유효，1례계속진전，1례실방，유효솔88％；2례D기환자1례유효，1례계속진전，유효솔50％。
AIM: To observe the efficacy and side reaction of superselective ophthalmic artery chemotherapy for retinoblastoma ( RB) . METHODS:Eleven cases (11 eyes) of RB, ranging from stage A to D according to the latest International Intraocular Retinoblastoma classification, were treated with melphalan infusion by the ophthalmic artery. RESULTS: Such intra -arterial chemotherapy was administered for 23 times and the patients were followed up for 3-12 months.During the follow-up, 8 cases were effective with significant tumor shrinking and calcification;2 patients progressed and received enucleation of eyeballs; 1 case was lost to follow-up. Postoperative transient nausea, vomiting and fever appeared in some cases, but serious complications were not found, such as death, stroke, myelosuppression,etc. CONCLUSION:Among 9 cases from group A, B and C, 7 cases were effective, 1 case continued to progress and 1 case was lost to follow-up, and the effective rate was 88%.In the 2 cases of group D, 1 case was effective and the other continueed to progress, so the effective rate was 50%.