国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2013年
12期
2501-2503
,共3页
真菌性角膜溃疡%透明质酸钠%药物治疗
真菌性角膜潰瘍%透明質痠鈉%藥物治療
진균성각막궤양%투명질산납%약물치료
fungal corneal ulcer%sodium hyaluronate%drug therapy
目的：回顾性分析透明质酸钠在真菌性角膜溃疡治疗中的效果。<br> 方法：2006-06以来，在我院接受药物治疗的真菌性角膜溃疡患者共178例178眼，其中2006-06/2008-06期间共81例81眼作为对照组，接受以那他霉素及氟康唑为主的传统抗真菌方案治疗；2008-06/2010-03期间97例97眼作为治疗组，在传统治疗方案基础上加用透明质酸钠治疗。对比分析两种治疗方法的效果。<br> 结果：治疗组97例，平均住院时间14．15±4．23d，治愈90例，治愈率92．8％，好转5例，占5．2％，无效2例，占2.1％，最终视力＞0．3者占51．6％。对照组81例，平均住院时间17．26±6．23d，治愈69例，治愈率85．2％，好转7例，占8．6％，无效5例，占6．2％，最终视力＞0．3者占39.5％。经统计学分析，两组的平均住院时间、治愈率、有效率及最终视力差异具有统计学意义（ P＜0．05），治疗组的平均住院时间短于对照组，治愈率及有效率高于对照组，最终视力好于对照组。<br> 结论：透明质酸钠可促进真菌性角膜溃疡愈合，提高治愈率，减少角膜瘢痕形成。
目的：迴顧性分析透明質痠鈉在真菌性角膜潰瘍治療中的效果。<br> 方法：2006-06以來，在我院接受藥物治療的真菌性角膜潰瘍患者共178例178眼，其中2006-06/2008-06期間共81例81眼作為對照組，接受以那他黴素及氟康唑為主的傳統抗真菌方案治療；2008-06/2010-03期間97例97眼作為治療組，在傳統治療方案基礎上加用透明質痠鈉治療。對比分析兩種治療方法的效果。<br> 結果：治療組97例，平均住院時間14．15±4．23d，治愈90例，治愈率92．8％，好轉5例，佔5．2％，無效2例，佔2.1％，最終視力＞0．3者佔51．6％。對照組81例，平均住院時間17．26±6．23d，治愈69例，治愈率85．2％，好轉7例，佔8．6％，無效5例，佔6．2％，最終視力＞0．3者佔39.5％。經統計學分析，兩組的平均住院時間、治愈率、有效率及最終視力差異具有統計學意義（ P＜0．05），治療組的平均住院時間短于對照組，治愈率及有效率高于對照組，最終視力好于對照組。<br> 結論：透明質痠鈉可促進真菌性角膜潰瘍愈閤，提高治愈率，減少角膜瘢痕形成。
목적：회고성분석투명질산납재진균성각막궤양치료중적효과。<br> 방법：2006-06이래，재아원접수약물치료적진균성각막궤양환자공178례178안，기중2006-06/2008-06기간공81례81안작위대조조，접수이나타매소급불강서위주적전통항진균방안치료；2008-06/2010-03기간97례97안작위치료조，재전통치료방안기출상가용투명질산납치료。대비분석량충치료방법적효과。<br> 결과：치료조97례，평균주원시간14．15±4．23d，치유90례，치유솔92．8％，호전5례，점5．2％，무효2례，점2.1％，최종시력＞0．3자점51．6％。대조조81례，평균주원시간17．26±6．23d，치유69례，치유솔85．2％，호전7례，점8．6％，무효5례，점6．2％，최종시력＞0．3자점39.5％。경통계학분석，량조적평균주원시간、치유솔、유효솔급최종시력차이구유통계학의의（ P＜0．05），치료조적평균주원시간단우대조조，치유솔급유효솔고우대조조，최종시력호우대조조。<br> 결론：투명질산납가촉진진균성각막궤양유합，제고치유솔，감소각막반흔형성。
METHODS: Since June, 2006, there were 178 patients ( 178 eyes ) with fungal corneal ulcer receiving medical treatment in our hospital.Among them, 81 patients ( 81 eyes ) as the control group received the traditional antifungal treatment with the natamycin and fluconazole being the major medicine, from June 2006 to June 2008. While, 97 patients ( 97 eyes ) as the treatment group received sodium hyaluronate treatment based on traditional antifungal treatment during the period of June 2008 to March 2010.Effects of two therapeutic methods were compared and analyzed. <br> RESULTS: Of the 97 cases in the treatment group, the average hospital stay was: 14.15 ±4.23d, with 90 cases ( 92.8%) cured, 5 cases ( 5.2%) improved, 2 cases ( 2.1%) ineffective, the final visual acuity of 51.6%patients better than 0.3.Of the 81 cases in the control group, average hospital stay was: 17.26 ±6.23d, with 69 cases (85.2%) cured, 7 cases (8.6%) improved, 5 cases (6.2%) ineffective, the final visual acuity of 39.5%patients better than 0.3. After statistical analysis, the average hospital stay, the cure rate, the effective rate and the final visual acuity in both groups showed statistically significant difference (P<0.05).The average hospital stay of the treatment group was shorter than that of the control group, while the cure rate and effective rate and the final visual acuity was better than that of the control group. <br> CONCLUSION:Sodium hyaluronate can promote fungal corneal ulcer healing, improve the cure rate and reduce the formation of corneal scar.
