CAJ | 학술논문

目的：研究基于自动分层算法的超高分辨率谱域 OCT （ UHR-OCT）用于角膜上皮厚度测量的重复性。 　　方法：使用自行搭建的UHR-OCT系统采集18例健康受试者（年龄23．2±0．9岁）左眼的图像，应用一种基于轴向梯度信息和最短路径的分层算法对得到的SD-OCT图像进行边界探测获取角膜上皮厚度。 　　结果：自动与手动的上皮分层的位置有很好的相关性（P＞0．05，配对t检验）。自动算法获取的6 mm范围平均上皮厚度为52．1±2．1μm，范围从50．3±1．8μm 到53．2±2.4μm，与手动分层之间的角膜上皮厚度差异为0．4±0.3μm。UHR-OCT自动算法重复测量上皮厚度的组内相关系数ICC和可重复性系数CoR分别为0．90±0．05，1.44±0.01μm。 　　结论：对于超高分辨率OCT，自动分层方法在角膜上皮厚度测量中有着很好的准确性和可重复性。
목적：연구기우자동분층산법적초고분변솔보역 OCT （ UHR-OCT）용우각막상피후도측량적중복성。 　　방법：사용자행탑건적UHR-OCT계통채집18례건강수시자（년령23．2±0．9세）좌안적도상，응용일충기우축향제도신식화최단로경적분층산법대득도적SD-OCT도상진행변계탐측획취각막상피후도。 　　결과：자동여수동적상피분층적위치유흔호적상관성（P＞0．05，배대t검험）。자동산법획취적6 mm범위평균상피후도위52．1±2．1μm，범위종50．3±1．8μm 도53．2±2.4μm，여수동분층지간적각막상피후도차이위0．4±0.3μm。UHR-OCT자동산법중복측량상피후도적조내상관계수ICC화가중복성계수CoR분별위0．90±0．05，1.44±0.01μm。 　　결론：대우초고분변솔OCT，자동분층방법재각막상피후도측량중유착흔호적준학성화가중복성。
AIM:To assess the repeatability of thickness profiles of corneal epithelium produced by aautomatic hierarchic algorithm that was applied to images obtained by a custom-built ultra-high resolution OCT ( UHR-OCT ) system. METHODS:Eighteen left eyes of 18 subjects (23.2±0.9) years;mean age±standard deviation) were imaged twice on non-consecutive days by a custom-built ultra-high resolution OCT ( UHR -OCT ) system. A hierarchic algorithm based on the axial gradient information and a shortest path search was developed to measure the corneal epithelial thickness profiles from the SD-OCT images. RESULTS: There was good correlation between theautomatic and manual hierarchy positions of the epithelium ( p >0.05, paired t -test ). The average epithelial thickness of the 6mm central corneal region determined by the automatic hierarchic algorithm was 52.1±2.1μm, ranging from 50.3 ±1.8μm to 53.2 ±2.4μm along the horizontal meridian. The epithelial thickness differences between automatic and manual hierarchy by the UHR-OCT systems were 0.4 ±0.3μm.The intraclass correlation coefficients ( ICC ) and coefficients of repeatability ( CoR ) with repeated UHR - OCT measurements for epithelial thickness were 0.90±0.05 and 1.44±0.01μm respectively. CONCLUSION: Regarding UHR -OCT system, the custom -developed automatic hierarchy has good repeatability and accuracy for measuring the thickness of corneal epithelium.