CAJ | 학술논문

目的：观察羟苯磺酸钙对眼压已经手术控制的青光眼患者的视神经保护作用。 　　方法：选取本院2011-01/2012-02住院的原发性青光眼患者共78例89眼，按照数字表随机分为对照组和观察组，疗程6 mo。观察治疗前后两组患者视力、视网膜平均感光度、眼压、视盘形态学的变化，以及评价疗效。 　　结果：两组患者治疗前后视力、眼压、视盘形态学均无明显变化，差异无统计学意义。对照组患者治疗前后视网膜平均感光度无明显变化（14．75±5．17 vs 13．48±4．69），而治疗组患者经羟苯磺酸钙治疗，视网膜平均感光度明显改善（14．56±5．03 vs 18．9±5．77），差异有统计学意义（ P＜0.05），与对照组治疗后相比，差异亦有统计学意义（ P＜0.05）。对照组视网膜平均感光度改善率、稳定率、恶化率分别为10．3％，48．7％，41．0％；而观察组分别为64．1％，28．2％，7．7％，两组相比差异有统计学意义（P＜0．05）。 　　结论：羟苯磺酸钙能提高青光眼患者视网膜平均光敏感度，对眼压已控制的青光眼患者有视神经保护作用。
목적：관찰간분광산개대안압이경수술공제적청광안환자적시신경보호작용。 　　방법：선취본원2011-01/2012-02주원적원발성청광안환자공78례89안，안조수자표수궤분위대조조화관찰조，료정6 mo。관찰치료전후량조환자시력、시망막평균감광도、안압、시반형태학적변화，이급평개료효。 　　결과：량조환자치료전후시력、안압、시반형태학균무명현변화，차이무통계학의의。대조조환자치료전후시망막평균감광도무명현변화（14．75±5．17 vs 13．48±4．69），이치료조환자경간분광산개치료，시망막평균감광도명현개선（14．56±5．03 vs 18．9±5．77），차이유통계학의의（ P＜0.05），여대조조치료후상비，차이역유통계학의의（ P＜0.05）。대조조시망막평균감광도개선솔、은정솔、악화솔분별위10．3％，48．7％，41．0％；이관찰조분별위64．1％，28．2％，7．7％，량조상비차이유통계학의의（P＜0．05）。 　　결론：간분광산개능제고청광안환자시망막평균광민감도，대안압이공제적청광안환자유시신경보호작용。
AIM: To observe the protective effect of calcium dobesilate on optic nerve of glaucoma patients whose intraocular pressure has been under control through operation. METHODS: A total of 78 inpatients ( 89 eyes ) with glaucoma in this hospital from January, 2011 to February, 2012 were enrolled.All patients were randomly divided into treatment group and control group with 6 months in a course.The visual acuity, visual field ( mean sensibility, MS), and intraocular pressure were measured at the experiment onset and 6 months later to evaluate the clinical effect. RESULTS: There were no statistically significant differences in the visual acuity, intraocular pressure between the two groups neither at the experiment onset nor after 6 months (P>0.05).The mean sensibility (MS) of the treatment group was obviously improved (14.56 ± 5.03 vs 18.9 ±5.77, P<0.05 ) with statistically significant differences before and after the treatment, while the MS remained unchanged in the control group (14.75±5.17 vs 13.48±4.69).There are statistically significant difference between the treatment group and the control group. Compared to the ratio of improvement, stability, and deterioration in the control group ( 10.3%, 48.7%, 41.0%) , the indexes were changed obviously in the treatment group (64.1%, 28.2%, 7.7%,P<0.05) with statistically significant difference between the two groups.CONCLUSION:Calcium dobesilate can improve mean retinal sensitivity and protect the optic nerve in glaucoma patients whose intraocular pressure has been controlled.