CAJ | 학술논문

目的探讨子宫颈鳞癌组织中LATS2的表达情况及临床意义。方法采用免疫组化SP法检测20例正常宫颈组织和40例子宫颈鳞癌组织中LATS2的表达情况，分析其表达情况与宫颈鳞癌之间的关系。结果LATS2在宫颈鳞癌中的细胞核表达明显低于正常宫颈上皮( P <0.05)；LATS2的表达降低与患者的肿瘤大小及有无淋巴结转移明显相关(P<0.05)。结论LATS2在宫颈鳞癌中表达降低，其异常表达可能参与了宫颈鳞癌的发生发展。
목적탐토자궁경린암조직중LATS2적표체정황급림상의의。방법채용면역조화SP법검측20례정상궁경조직화40례자궁경린암조직중LATS2적표체정황，분석기표체정황여궁경린암지간적관계。결과LATS2재궁경린암중적세포핵표체명현저우정상궁경상피( P <0.05)；LATS2적표체강저여환자적종류대소급유무림파결전이명현상관(P<0.05)。결론LATS2재궁경린암중표체강저，기이상표체가능삼여료궁경린암적발생발전。
Objective To explore expression of LATS2 in cervical squamous cell cancer and its clinical signifi-cance. Methods The expression of LATS2 in 20 cases of normal cervical tissues and 40 cases of cervical squa-mous cell cancer by immunohistochemical SP were detected, and the relationship between LATS2 expression and cervical squamous cell cancer was analyzed. Results Nucleus expression of LATS2 was markedly decreased in cancer tissues compared to normal tissues (P<0.05). Decrease of LATS2 was significantly correlated with cancer patients' tumor size and lymph node metastasis (P<0.05). Conclusion Expression of LATS2 is markedly de-creased in cervical squamous cell cancer and the abnormal expression of LATS2 is likely to participate in the devel-opment and progress of cervical squamous cell cancer.