CAJ | 학술논문

　　目的：评估不同使用量的头孢噻肟钠-舒巴坦钠复合制剂与鲍曼不动杆菌耐药的相关性。方法：将经生化分析和药敏鉴定的114株痰培养鲍曼不动杆菌随机分为实验组和对照组。实验组（57株）采用头孢噻肟钠-舒巴坦钠复合制剂抑菌，对照组（57株）采用头孢噻肟钠单方制剂抑菌，依据不同抗菌药平均每天每100床患者用药的频率和同期对鲍曼不动杆菌的耐药率变化，对两组抗菌药物使用量与耐药率进行相关性统计分析。结果：实验组对鲍曼不动杆菌的平均耐药率为42.4%，对照组的耐药率为63.5%。头孢噻肟钠-舒巴坦钠复方制剂与鲍曼不动杆菌对该药耐药率正相关（P=0.0288）；头孢噻肟钠单方制剂与鲍曼不动杆菌耐药率也正相关（P=0.0093）。相对于单方制剂用药，复方用药可有效改善耐药菌对抗菌药的敏感性。结论：头孢噻肟钠-舒巴坦钠抗菌药物使用量与鲍曼不动杆菌耐药性存在相关性，且随着抗菌药使用量的增加，细菌的耐药性越大。
　　목적：평고불동사용량적두포새우납-서파탄납복합제제여포만불동간균내약적상관성。방법：장경생화분석화약민감정적114주담배양포만불동간균수궤분위실험조화대조조。실험조（57주）채용두포새우납-서파탄납복합제제억균，대조조（57주）채용두포새우납단방제제억균，의거불동항균약평균매천매100상환자용약적빈솔화동기대포만불동간균적내약솔변화，대량조항균약물사용량여내약솔진행상관성통계분석。결과：실험조대포만불동간균적평균내약솔위42.4%，대조조적내약솔위63.5%。두포새우납-서파탄납복방제제여포만불동간균대해약내약솔정상관（P=0.0288）；두포새우납단방제제여포만불동간균내약솔야정상관（P=0.0093）。상대우단방제제용약，복방용약가유효개선내약균대항균약적민감성。결론：두포새우납-서파탄납항균약물사용량여포만불동간균내약성존재상관성，차수착항균약사용량적증가，세균적내약성월대。
Objective: To assess the correlation between consumption of cefotaxime sodium-sulbactam sodium and resistance rates of Acinetobacter baumannii. Methods: 114 strains of Acinetobacter baumanni , confirmed by biochemical analysis and drug susceptibility test, were randomly assigned to experiment group(n=57, cefotaxime sodium-sulbactam sodium were administered ) or control group(n=57, cefotaxime sodium only was administered ). According to antibacterial consumption which defined as daily doses per 100 bed-days and the resistance rate of Acinetobacter baumanni , the correlation was statistically analyzed between the two groups. Results: The average resistance rate against acinetobacter baumanni in the experimental group was 42.4%, the control group was 63.5%.The resistance to consumption of cefotaxime sodium-sulbactam sodium was significantly correlated with resistance to baumanni (P=0.0288). The consumption of cefotaxime sodium was significantly correlated with resistance to baumanni (P=0.0093). As compared with cefofarime only,cefofaxime sodium-sulbactan sodium can effectively improve the sensitivity of the resistant bacteria to antimicrobial drugs. Conclusion:There is a relationship between antibacterial consumption and resistance rates of acinetobacter baumanni , and with the increased use of antimicrobial drugs, the bacterial resistance is stronger.