临床药物治疗杂志
臨床藥物治療雜誌
림상약물치료잡지
CLINICAL MEDICATION JOURNAL
2013年
4期
30-33
,共4页
α-硫辛酸%2型糖尿病%周围神经病变%TSS
α-硫辛痠%2型糖尿病%週圍神經病變%TSS
α-류신산%2형당뇨병%주위신경병변%TSS
Alpha-lipoic acid%Type2 diabetes%Peripheral neuropathy%TSS
目的：评价α-硫辛酸治疗2型糖尿病周围神经病变的有效性。方法：将2011年至2012年我院收治2型糖尿病周围神经病变患者共64例随机分为试验组（n=32）和对照组（n=32），其中试验组使用α-硫辛酸治疗,对照组使用谷胱甘肽治疗,治疗前后对其进行TSS。结果：试验组患者应用α-硫辛酸治疗后，TSS较治疗前改善4.37分(P ＜0.01)，且未见明显不良反应。结论：α-硫辛酸相对于谷胱甘肽可明显改善2型糖尿病患者周围神经病变的症状，且无明显不良反应。
目的：評價α-硫辛痠治療2型糖尿病週圍神經病變的有效性。方法：將2011年至2012年我院收治2型糖尿病週圍神經病變患者共64例隨機分為試驗組（n=32）和對照組（n=32），其中試驗組使用α-硫辛痠治療,對照組使用穀胱甘肽治療,治療前後對其進行TSS。結果：試驗組患者應用α-硫辛痠治療後，TSS較治療前改善4.37分(P ＜0.01)，且未見明顯不良反應。結論：α-硫辛痠相對于穀胱甘肽可明顯改善2型糖尿病患者週圍神經病變的癥狀，且無明顯不良反應。
목적：평개α-류신산치료2형당뇨병주위신경병변적유효성。방법：장2011년지2012년아원수치2형당뇨병주위신경병변환자공64례수궤분위시험조（n=32）화대조조（n=32），기중시험조사용α-류신산치료,대조조사용곡광감태치료,치료전후대기진행TSS。결과：시험조환자응용α-류신산치료후，TSS교치료전개선4.37분(P ＜0.01)，차미견명현불량반응。결론：α-류신산상대우곡광감태가명현개선2형당뇨병환자주위신경병변적증상，차무명현불량반응。
Objective: To evaluate the effect of alpha-lipoic acid on diabetic peripheral neuropathy. Methods: A lot of 64 diabetic peripheral neuropathy patients col ected from 2011 to 2012 in our hospital were assigned to alpha-lipoic acid (n=32, experiment group) or glutathione(n=32, control group), for 14 days. The primary outcome measure was the change from baseline of the TSS, including stabbing pain, burning pain, paresthesia, and asleep numbness of the feet. Results: After use of alpha-lipoic acid, the TSS decreased significantly by 4.37 points, as compared with that at the baseline(P<0.01). TSS was more significantly decreased in the experiment group than in the control group (P<0.05). No adverse reactions occurred in both groups. Conclusions: As compared with glutathione, ALA could improved neuropathic symptoms effectively with no adverse reactions.
