CAJ | 학술논문

胆道闭锁(BA)以胆道系统进行性炎症和纤维性梗阻为特征,在新生儿期出现梗阻性黄疸症状,如果不能有效治疗最终肝纤维化进展导致终末期肝衰竭和死亡.Kasai手术是治疗BA主要的手术方法,但并非所有病例在术后都获得黄疸清除和自体肝存活,为提高治疗效果需要在手术时机、手术方式、术后用药以及并发症的预防和处理上进行优化,现对目前相关临床研究和治疗现状进行总结.
담도폐쇄(BA)이담도계통진행성염증화섬유성경조위특정,재신생인기출현경조성황달증상,여과불능유효치료최종간섬유화진전도치종말기간쇠갈화사망.Kasai수술시치료BA주요적수술방법,단병비소유병례재술후도획득황달청제화자체간존활,위제고치료효과수요재수술시궤、수술방식、술후용약이급병발증적예방화처리상진행우화,현대목전상관림상연구화치료현상진행총결.
Biliary atresia (BA) is characterized of progressive inflammation and obstruction with fibrosis in biliary system and presents symptoms with obstructive jaundice in neonatal period,if its treatment is not ineffectively may lead to progressive liver fibrosis,end-stage liver failure and die within 2 years.Kasai procedure is the major method in BA treatment,but not all cases have postoperative jaundice clearance and survive with native liver,it is need to optimize the choice of surgical time and methods,postoperative protocol with medicine,prevention and treatment of complications for improving the postoperative therapeutic effect.In this paper,the current option of clinical research and statue in Kasai procedure were summarized.