CAJ | 학술논문

　　目的探讨影响阿尔茨海默病(AD)认知损害程度的相关因素。方法收集2009年1月至2012年12月4年间在神经内科收治的已经确诊的AD患者病例资料共132例，按认知功能损害程度，划分轻度组58例和中重组84例，对其临床资料进行回顾性分析。结果单因素分析显示，轻度A D组和中重度AD组在年龄、职业、精神行为、病程、头部CT萎缩程度、MMSE评分、ADL评分和用药情况等方面相比有显著性差异（P﹤0.05）,而性别、文化程度、饮酒史、和家族遗传史在两组间差异无统计学意义（P>0.05）。多因素分析显示，与AD认知损害程度密切相关的因素为病程、精神行为异常和头部CT萎缩程度，OR值分别为4.546（95%CI1.684-9.263）5.321(95%CI：1.561-10.243) and 3.863(95%CI：1.254-7.864)。结论精神行为异常、病程和头部CT萎缩程度是AD的认知障碍程度的危险因素。
　　목적탐토영향아이자해묵병(AD)인지손해정도적상관인소。방법수집2009년1월지2012년12월4년간재신경내과수치적이경학진적AD환자병례자료공132례，안인지공능손해정도，화분경도조58례화중중조84례，대기림상자료진행회고성분석。결과단인소분석현시，경도A D조화중중도AD조재년령、직업、정신행위、병정、두부CT위축정도、MMSE평분、ADL평분화용약정황등방면상비유현저성차이（P﹤0.05）,이성별、문화정도、음주사、화가족유전사재량조간차이무통계학의의（P>0.05）。다인소분석현시，여AD인지손해정도밀절상관적인소위병정、정신행위이상화두부CT위축정도，OR치분별위4.546（95%CI1.684-9.263）5.321(95%CI：1.561-10.243) and 3.863(95%CI：1.254-7.864)。결론정신행위이상、병정화두부CT위축정도시AD적인지장애정도적위험인소。
objective To investigate the related factors affecting levels of cognitive impairment in Alzheimer’s disease (AD). Methods: 132 AD patients selected from Department of Neurology were examined. Among the patients with different levels of cognitive impairment, 58 were mild and 84 were moderate to severe. The data were analyzed by the conditional Logistic regression. Results: The results showed long disease duration, with behavioral and psychological symptoms and the head nerve atrophy levele were independent risk factors for AD with severe cognitive impairment.TheOR(oddsratio)were 4.546(95%CI1.684-9.263)5.321 (95%CI: 1.561-10.243) and 3.863(95%CI:1.254-7.864) respectively.Conclusion: long disease duration, with behavioral and psychological symptoms and the head nerve atrophy levele were independent risk factors of cognitive impairment in AD.