CAJ | 학술논문

目的：观察胶原贴敷料联合面部外治法治疗寻常型痤疮的疗效和安全性。方法将150例寻常型痤疮患者随机分成两组，治疗组75例，对照组75例。治疗组和对照组均给予面部外治法，每周1次，同时予罗红霉素缓释胶囊0.3g，qd，口服；甲硝唑0.2g，Bid，口服，治疗组同时给予胶原贴敷料每晚1次，连用1周，然后改为隔日1次，疗程共8周。于治疗前、治疗4周、治疗8周分别观察患者的皮损情况、色素沉着情况、皮脂溢出情况及不良反应。结果治疗组有效率为95.83%，对照组94.66%，皮损综合情况疗效比较差异无统计学意义，但是，治疗后皮脂溢出情况、色素沉着情况较对照组差异有统计学意义，两组均未见明显不良反应。结论胶原贴敷料苷联合面部外治法治疗寻常型错痤疮疗效好、安全。且胶原贴敷料能明显改善面部油脂溢出和面部痤疮后色素沉着。
목적：관찰효원첩부료연합면부외치법치료심상형좌창적료효화안전성。방법장150례심상형좌창환자수궤분성량조，치료조75례，대조조75례。치료조화대조조균급여면부외치법，매주1차，동시여라홍매소완석효낭0.3g，qd，구복；갑초서0.2g，Bid，구복，치료조동시급여효원첩부료매만1차，련용1주，연후개위격일1차，료정공8주。우치료전、치료4주、치료8주분별관찰환자적피손정황、색소침착정황、피지일출정황급불량반응。결과치료조유효솔위95.83%，대조조94.66%，피손종합정황료효비교차이무통계학의의，단시，치료후피지일출정황、색소침착정황교대조조차이유통계학의의，량조균미견명현불량반응。결론효원첩부료감연합면부외치법치료심상형착좌창료효호、안전。차효원첩부료능명현개선면부유지일출화면부좌창후색소침착。
Objective To observe the efficacy and safety of compound collagen dressing combined with facial external ues in the treatment of acne vulgaris. Methods 150 cases with acne vulgaris were divided into two groups randomly. Patients in the treatment group and the control group were given facial external treatment once a week and compound roxithromycin, 0.3g, Po, Qd, metronidazole,0.2g,Po,Bid. At the same time, the patients in the treatment group were given collagen dressing one piece every night for 1 week. Then, the dosage was reduced to one piece every other night for 3 weeks. Results The response rates were 95.83% and 94.66% respectively. There was no significant difference between the treatment group and the control group. But the rate of seborrhea and pigment fade was significant difference between the treatment group and the control group after the treatment of collagen dressing. No significant adverse events were found. Conclusion Compound collagen dressing combined with facial external treatment is effective and safe in the treatment of acne vulgaris. Sebum overflow reduce and the extinction of pigment expedite after treated in combination with dressing collagen.