CAJ | 학술논문

目的：对垂体后叶素与去甲肾上腺素治疗感染性休克的临床效果进行研究。方法以2011年3月～2013年6月在我院住院治疗的36例感染性休克患者为研究对象，按照不同的治疗方法分成观察组和对照组，观察组18例，采用垂体后叶素进行复苏治疗，对照组18例，采用去甲肾上腺素进行复苏治疗，同时监测两组患者血压、血气及肝肾功能等。结果观察组6h复苏成功率为83.3%，明显高于对照组50.0%，多脏器功能不全（MODS）的发生率为27.8%，明显低于对照组61.1%，治疗1个月病死率为16.7%，明显低于对照组50.0%，两组相比差异有统计学意义（P＜0.05）；观察组与对照组治疗前乳酸浓度相比差异无统计学意义（P＞0.05），治疗12h、24h后观察组乳酸清除率明显高于对照组，相比差异有统计学意义（P＜0.05）。结论通过垂体后叶素治疗感染性休克患者，患者复苏成功率高，组织细胞灌注不足或者缺氧状态的改善明显比去甲肾上腺素效果好，值得临床推广应用。
목적：대수체후협소여거갑신상선소치료감염성휴극적림상효과진행연구。방법이2011년3월～2013년6월재아원주원치료적36례감염성휴극환자위연구대상，안조불동적치료방법분성관찰조화대조조，관찰조18례，채용수체후협소진행복소치료，대조조18례，채용거갑신상선소진행복소치료，동시감측량조환자혈압、혈기급간신공능등。결과관찰조6h복소성공솔위83.3%，명현고우대조조50.0%，다장기공능불전（MODS）적발생솔위27.8%，명현저우대조조61.1%，치료1개월병사솔위16.7%，명현저우대조조50.0%，량조상비차이유통계학의의（P＜0.05）；관찰조여대조조치료전유산농도상비차이무통계학의의（P＞0.05），치료12h、24h후관찰조유산청제솔명현고우대조조，상비차이유통계학의의（P＜0.05）。결론통과수체후협소치료감염성휴극환자，환자복소성공솔고，조직세포관주불족혹자결양상태적개선명현비거갑신상선소효과호，치득림상추엄응용。
Objective To study the clinical effect of vasopressin and norepinephrine in the treatment of infective shock. Methods Thirty-six inpatients with infective shock in our hospital from March 2011 to June 2013 were selected as the study objects.The patients were divided into the observation group and the control group according to different treatment methods.18 cases in the observation group were treated with vasopressin for resuscitation,while 18 cases in the control group were treated with norepinephrine for resuscitation.The blood pressure,blood gas,liver and kidney function of two groups were monitored at the same time. Results The recovery success rate within 6h in the observation group(83.3%) was significantly higher than that in the control group(50.0%).The incidence of multiple organ dysfunction syndrome(MODS) in the observation group(27.8%) was significantly lower than that in the control group(61.1%).The mortality after 1 month of treatment in the observation group(16.7%) was significantly lower than that in the control group(50.0%).There were significant differences between two groups(P<0.05).There was not significant difference in the lactate concentration before the treatment between two groups(P>0.05).The lactate clearance rate at 12h,24h after the treatment in the observation group were significantly higher than those in the control group,there were significant differences between two groups(P<0.05). Conclusion Compare with norepinephrine,vasopressin in the treatment of infective shock has higher recovery success rate and more significant improvement for tissue hypoperfusion or hypoxia,so it is worthy of application in clinic.