CAJ | 학술논문

目的：探讨培门冬酶治疗结外NK/T细胞淋巴瘤的疗效及安全性。方法选择2012年1月-2013年9月中南大学湘雅医学院附属肿瘤医院淋巴瘤血液内科收治的结外NK/T细胞淋巴瘤（鼻型）患者28例，按治疗药物的不同将患者分成左旋门冬酰胺酶组（13例）和培门冬酶组（15例）。左旋门冬酰胺酶组接受左旋门冬酰胺酶联合吉西他滨、奥沙利铂、地塞米松治疗，培门冬酶组接受培门冬酶联合吉西他滨、奥沙利铂、地塞米松治疗，同时两组均结合放疗。比较两组治疗有效率及不良反应发生率。结果28例患者的总有效率为89.3％（25/28）。左旋门冬酰胺酶组有效率为84.6％（11/13），培门冬酶组有效率为93.3％（14/15），差异无统计学意义（χ2＝0.553，P＝0.457）。左旋门冬酰胺酶组患者3~4度消化道反应、高血糖（空腹血糖＞7.0 mmol/L）、过敏反应的发生率均高于培门冬酶组（P＜0.05）。结论培门冬酶对结外NK/T细胞淋巴瘤的近期治疗效果较好，且较左旋门冬酰胺酶不良反应发生率低，安全性高，为临床治疗提供了有益参考。
목적：탐토배문동매치료결외NK/T세포림파류적료효급안전성。방법선택2012년1월-2013년9월중남대학상아의학원부속종류의원림파류혈액내과수치적결외NK/T세포림파류（비형）환자28례，안치료약물적불동장환자분성좌선문동선알매조（13례）화배문동매조（15례）。좌선문동선알매조접수좌선문동선알매연합길서타빈、오사리박、지새미송치료，배문동매조접수배문동매연합길서타빈、오사리박、지새미송치료，동시량조균결합방료。비교량조치료유효솔급불량반응발생솔。결과28례환자적총유효솔위89.3％（25/28）。좌선문동선알매조유효솔위84.6％（11/13），배문동매조유효솔위93.3％（14/15），차이무통계학의의（χ2＝0.553，P＝0.457）。좌선문동선알매조환자3~4도소화도반응、고혈당（공복혈당＞7.0 mmol/L）、과민반응적발생솔균고우배문동매조（P＜0.05）。결론배문동매대결외NK/T세포림파류적근기치료효과교호，차교좌선문동선알매불량반응발생솔저，안전성고，위림상치료제공료유익삼고。
Objective To explore the therapeutic efficacy and adverse reactions of PEG-asparaginase in patients with extranodal NK/T-cell lymphoma. Methods Twenty-eight patients with extranodal NK/T-cell lymphoma from January 2012 to September 2013 in department of lymphoma and hematology,Affiliated Tumor Hospital of Xiangya Medical School,Central South University. Different drug treatment were divided into groups A( given L-asparaginase combined with gemxibine,oxali-platine,dexamisone,n=13),B(given PEG-asparaginase combined with gemxibine,oxaliplatine,dexamisone,n=15). The 2 groups were also given radiotherapy. The effective rate,adverse reactions were compared between 2 groups. Results The total effective rate was 89. 3%( 25/28 ). The effective rate of group A was 84. 6%( 11/13 ), that of group B was 93. 3%(14/15),the difference was not significant(χ2 =0. 553,P=0. 457). The incidences of 3~4 degrees of gastrointestinal reac-tion,hyperglycemia(FPG>7. 0 mmol/L),anaphylactic reaction in group A were higher than those in group B(P<0. 05). Conclusion PEG-asparaginase is of good therapeutic effects on extranodal NK/T-cell lymphoma,and its incidence of adverse reactions is lower and safety higher than those of L-asparaginase,which provides helpful basis for clinical treatment.