中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2014年
18期
2087-2089
,共3页
流产,先兆%妊娠结局%绒毛膜促性腺激素,β亚单位,人%孕酮%雌二醇
流產,先兆%妊娠結跼%絨毛膜促性腺激素,β亞單位,人%孕酮%雌二醇
유산,선조%임신결국%융모막촉성선격소,β아단위,인%잉동%자이순
Abortion,threatened%Pregnancy outcome%Chorionic gonadotropin,beta subunit,human%Progester-one%Estradiol
目的：探讨孕早期首次孕酮水平与妊娠结局的关系。方法选取2012年7月-2013年7月浙江省绍兴市人民医院浙江大学绍兴医院妇科门诊收治的年龄18~45岁早孕妇女，其中先兆流产88例、难免流产93例，另随机选取同时期正常早孕妇女88例为对照组。采用化学发光技术检测受检者血清β人绒毛膜促性腺激素（β-HCG）、孕酮、雌二醇水平，运用受试者工作特征（ ROC）曲线确定不良妊娠结局的孕酮水平临界值。结果难免流产组血清β-HCG、孕酮、雌二醇水平较对照组和先兆流产组均减低（ P＜0.01）；对照组与先兆流产组比较，差异均无统计学意义（P＞0.05）。当孕酮取值44.8 nmol/L 时，预测难免流产的敏感度为90.5％，特异度为86.1％，约登指数为0.766。结论难免流产者血清β-HCG、孕酮、雌二醇水平较正常孕妇和先兆流产者均减低，首次孕酮水平低于44.8 nmol/L预示不良妊娠结局。
目的：探討孕早期首次孕酮水平與妊娠結跼的關繫。方法選取2012年7月-2013年7月浙江省紹興市人民醫院浙江大學紹興醫院婦科門診收治的年齡18~45歲早孕婦女，其中先兆流產88例、難免流產93例，另隨機選取同時期正常早孕婦女88例為對照組。採用化學髮光技術檢測受檢者血清β人絨毛膜促性腺激素（β-HCG）、孕酮、雌二醇水平，運用受試者工作特徵（ ROC）麯線確定不良妊娠結跼的孕酮水平臨界值。結果難免流產組血清β-HCG、孕酮、雌二醇水平較對照組和先兆流產組均減低（ P＜0.01）；對照組與先兆流產組比較，差異均無統計學意義（P＞0.05）。噹孕酮取值44.8 nmol/L 時，預測難免流產的敏感度為90.5％，特異度為86.1％，約登指數為0.766。結論難免流產者血清β-HCG、孕酮、雌二醇水平較正常孕婦和先兆流產者均減低，首次孕酮水平低于44.8 nmol/L預示不良妊娠結跼。
목적：탐토잉조기수차잉동수평여임신결국적관계。방법선취2012년7월-2013년7월절강성소흥시인민의원절강대학소흥의원부과문진수치적년령18~45세조잉부녀，기중선조유산88례、난면유산93례，령수궤선취동시기정상조잉부녀88례위대조조。채용화학발광기술검측수검자혈청β인융모막촉성선격소（β-HCG）、잉동、자이순수평，운용수시자공작특정（ ROC）곡선학정불량임신결국적잉동수평림계치。결과난면유산조혈청β-HCG、잉동、자이순수평교대조조화선조유산조균감저（ P＜0.01）；대조조여선조유산조비교，차이균무통계학의의（P＞0.05）。당잉동취치44.8 nmol/L 시，예측난면유산적민감도위90.5％，특이도위86.1％，약등지수위0.766。결론난면유산자혈청β-HCG、잉동、자이순수평교정상잉부화선조유산자균감저，수차잉동수평저우44.8 nmol/L예시불량임신결국。
Objective To assess the relationship between the first-time progesterone levels and the outcome of early pregnancy. Methods Women with early pregnancy admitted to the department of gynecology in Shaoxing People's Hospital were selected. Among them,88 suffered from threatened abortion and 93 suffered from inevitable abortion. Another 88 women with early pregnancy over the same period were selected as control group. Chemoluminescence method was used to determine the levels ofβ-HCG,progesterone and estradiol. Receiver-operator characteristic( ROC)curves was used to determine the cut-off point of serum progesterone level in predicting the adverse outcome in early pregnancy. Results The levels of serumβ-HCG,proges-terone and estradiol in inevitable abortion group were significantly lower than those of control group and threatened abortion group (P<0. 01),but the control group and threatened abortion group showed no statistically significant difference(P>0. 05). The cut-off point of serum progesterone for predicting the adverse outcome in early pregnancy was 44. 8 nmol/L,with a sensitivity of 90. 5% and specificity of 86. 1%,and the Youden's index was 0. 766. Conclusion The levels of serumβ-HCG,progesterone and estradiol in inevitable abortion group are significantly lower than those of control group and threatened abortion group. The au-thors consider that serum progesterone levels lower than 44. 8 nmol/L may be an indicator of adverse pregnancy outcomes.
