中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2014年
18期
77-77
,共1页
小细胞肺癌%异环磷酰胺%足叶乙甙%顺铂
小細胞肺癌%異環燐酰胺%足葉乙甙%順鉑
소세포폐암%이배린선알%족협을대%순박
Smal celllung cancer%ifosfamide%cisplatin%etoposide
目的:观察异环磷酰胺(IFO)、足叶乙甙(VP-16)及顺铂(DDP)联合组成的IEP方案治疗小细胞肺癌的临床疗效和不良反应。方法对22例小细胞肺癌患者应用IEP方案化疗:IFO 1200mg/m2静脉滴注,连用1~5日;分别于IFO后0、4、8h静脉推注美斯纳(Mesna)0.4g;VP-1675mg静脉滴注,连用1~5日;DDP 20mg/m2,连用1~5日;每3~4周为重复周期,3~4周期为一疗程。结果化疗3~4周期后,22例患者中CR 3例,PR 15例。总有效率为81.8%。主要不良反应为骨髓抑制:粒细胞减少发生率为68.5%,Ⅲ~Ⅳ度为31.8%。结论 IEP方案治疗小细胞肺癌有较好的疗效,值得进一步研究。
目的:觀察異環燐酰胺(IFO)、足葉乙甙(VP-16)及順鉑(DDP)聯閤組成的IEP方案治療小細胞肺癌的臨床療效和不良反應。方法對22例小細胞肺癌患者應用IEP方案化療:IFO 1200mg/m2靜脈滴註,連用1~5日;分彆于IFO後0、4、8h靜脈推註美斯納(Mesna)0.4g;VP-1675mg靜脈滴註,連用1~5日;DDP 20mg/m2,連用1~5日;每3~4週為重複週期,3~4週期為一療程。結果化療3~4週期後,22例患者中CR 3例,PR 15例。總有效率為81.8%。主要不良反應為骨髓抑製:粒細胞減少髮生率為68.5%,Ⅲ~Ⅳ度為31.8%。結論 IEP方案治療小細胞肺癌有較好的療效,值得進一步研究。
목적:관찰이배린선알(IFO)、족협을대(VP-16)급순박(DDP)연합조성적IEP방안치료소세포폐암적림상료효화불량반응。방법대22례소세포폐암환자응용IEP방안화료:IFO 1200mg/m2정맥적주,련용1~5일;분별우IFO후0、4、8h정맥추주미사납(Mesna)0.4g;VP-1675mg정맥적주,련용1~5일;DDP 20mg/m2,련용1~5일;매3~4주위중복주기,3~4주기위일료정。결과화료3~4주기후,22례환자중CR 3례,PR 15례。총유효솔위81.8%。주요불량반응위골수억제:립세포감소발생솔위68.5%,Ⅲ~Ⅳ도위31.8%。결론 IEP방안치료소세포폐암유교호적료효,치득진일보연구。
Objective Effect of ifosfamide (IFO), Ashikagayo Oto (VP-16) and cisplatin (DDP) clinical efficacy and adverse effects of IEP regimen combined with composition of the treatment of smal celllung cancer. Method In 22 cases of smal celllung cancer were treated with IEP regimen: IFO 1200mg/m2 IV drip, for 1 - 5 days after IFO respectively; 0, 4, 8h infusion mesna (Mesna) 0.4g; VP-16 75mg IV drip, for 1 - 5 days; DDP 20mg/m2, for 1 - 5 days each; 3 to 4 weeks to repeat the cycle, 3 - 4 cycles for a course. Result 3 to 4 cycles of chemotherapy, 3 cases in 22 cases of CR, 15 cases of PR. The total effective rate was 81.8%. The main adverse reactions were bone marrow suppression:neutropenia occurred in 68.5%, grade II or IV 31.8%. Conclusion P regimen in the treatment of smal celllung cancer has a good effect, worthy of further study.