CAJ | 학술논문

目的：观察急性大面积脑梗死早期应用尼莫地平静滴的临床疗效。方法选择急性发病的86例大面积脑梗死病人随机分成治疗组和对照组。治疗组予尼莫地平静滴，10毫克/日，连滴10天。对照组除不用尼莫地平外，其他治疗同治疗组。观察用药前、后两组NIHSS评分、Barthel指数和Rankin量表评分变化，比较两组疗效。结果治疗前两组NIHSS评分、Barthel指数和Rankin量表评分均无明显差异。治疗后治疗组NIHSS评分和Ranki评分均明显低于对照组，而Barthel指数均明显高于对照组，差异具有显著意义（P<0.01），结论早期静滴尼莫地平治疗急性大面积脑梗死疗效显著，副作用较小，安全性好。
목적：관찰급성대면적뇌경사조기응용니막지평정적적림상료효。방법선택급성발병적86례대면적뇌경사병인수궤분성치료조화대조조。치료조여니막지평정적，10호극/일，련적10천。대조조제불용니막지평외，기타치료동치료조。관찰용약전、후량조NIHSS평분、Barthel지수화Rankin량표평분변화，비교량조료효。결과치료전량조NIHSS평분、Barthel지수화Rankin량표평분균무명현차이。치료후치료조NIHSS평분화Ranki평분균명현저우대조조，이Barthel지수균명현고우대조조，차이구유현저의의（P<0.01），결론조기정적니막지평치료급성대면적뇌경사료효현저，부작용교소，안전성호。
Objective To study the effect of early application of nimodipine injection on acute large-area cerebral infarction. Methods 86 patients diagnosed as large-area cerebral infarction were randomly divided into two groups(treatment group and control group). Nimodipine was given to the treatment group with 10mg each day for 10 days. The control group was given al treatment drug except nimodipine. The change of the NIHSS, Barthel Index (BI) and Rankin scales were adopted for statistical analysis to compare the differential effect between the two groups. Results NIHSS, BI and Ranki scales were comparable between two groups before treatment (P>0.05) . Compared with the control group, the Ranki scale of the treatment group was obviously decreased (P<0.01), while the NIHSS and BI scales were increased obviously after treated with nimodipine(P<0.01) . Conclusions Early use of nimodipine can lead to the improvement of neurological function in patients of acute large-area cerebral infarction securely and with few side effects.