CAJ | 학술논문

目的：探讨自拟脑瘤方辅助化疗治疗脑胶质瘤的临床效果及安全性，为中药辅助治疗脑胶质瘤提供更多的参考依据。方法选择符合入组标准的184例脑胶质瘤术后放疗后患者，并将其随机分为治疗组（替莫唑胺+脑瘤方）和对照组（替莫唑胺）。观察和比较两组患者的临床疗效，毒副反应的发生情况以及生活质量的改善情况。结果治疗组和对照组患者的治疗总有效率分别为60.7％、50.0％，治疗组优于对照组，但差异无统计学意义（P=0.402）。治疗组卡氏评分的改善情况和治疗后的卡氏评分均显著优于对照组（P<0.05）。治疗组不良反应的总发生率显著低于对照组（P<0.001）。结论自拟脑瘤方联合替莫唑胺治疗脑胶质瘤，能显著改善患者的生活质量，并降低毒副反应，而且其临床治疗效果优于对照组，值得临床应用推广。
목적：탐토자의뇌류방보조화료치료뇌효질류적림상효과급안전성，위중약보조치료뇌효질류제공경다적삼고의거。방법선택부합입조표준적184례뇌효질류술후방료후환자，병장기수궤분위치료조（체막서알+뇌류방）화대조조（체막서알）。관찰화비교량조환자적림상료효，독부반응적발생정황이급생활질량적개선정황。결과치료조화대조조환자적치료총유효솔분별위60.7％、50.0％，치료조우우대조조，단차이무통계학의의（P=0.402）。치료조잡씨평분적개선정황화치료후적잡씨평분균현저우우대조조（P<0.05）。치료조불량반응적총발생솔현저저우대조조（P<0.001）。결론자의뇌류방연합체막서알치료뇌효질류，능현저개선환자적생활질량，병강저독부반응，이차기림상치료효과우우대조조，치득림상응용추엄。
Objective To evaluate the clinical efficacy and safety of brain glioma treated by self-developed cerebroma-soup, in order to provide more evidence of the adjuvant treatment for glioma. Methods The selected 184 glioma patients who had op-eration and radiotherapy were randomly divided into two groups:treatment group in which cerebroma-soup plus temozolomide were applied, and control group in which temozolomide was applied alone. Compared clinical efficacy, drug toxicity and quality of life of patients between the two groups. Results The total effective rate was 60.7%in the treatment group and 50.0%in the control group;the difference was not statistically significant between the two groups (P=0.402). The improvement of Karnofsky scores in the treatment group was significantly greater than those in control group (P<0.05). The Karnofsky scores after treat-ment were also higher in treatment group than in control group (P<0.05). In addition, the rate of adverse reaction in treatment group was significantly lower than that of control group (P<0.001). Conclusion Temozolomide combined with cerebroma-soup could improve the quality of life and reduce adverse reaction. It is a safe and effective therapy for glioma patients.