CAJ | 학술논문

邻苯二甲酸酯类（PAE）作为塑料增塑剂广泛使用，根据分子量不同分为高分子量和低分子量PAE。由于塑料制品在生产和生活中的广泛应用，人体极可能直接或间接暴露于 PAE。人体主要通过注射、经口、经皮及吸入4种方式暴露于PAEs。基于其对人体内分泌系统的影响，PAE被认为是一种环境内分泌干扰物。此外，PAE还具有生殖毒性作用，影响幼年个体生殖系统发育及成年个体生殖细胞发育分化。PAE通过活化过氧化物酶增殖物激活受体PPAR和D NA甲基化促进肝癌。PAE具有免疫毒性，抑制巨噬细胞免疫功能并促进过敏性哮喘。同时，PAE也是一种潜在致癌物质，对乳腺癌、卵巢癌等多种肿瘤的发生和发展具有促进作用。
린분이갑산지류（PAE）작위소료증소제엄범사용，근거분자량불동분위고분자량화저분자량PAE。유우소료제품재생산화생활중적엄범응용，인체겁가능직접혹간접폭로우 PAE。인체주요통과주사、경구、경피급흡입4충방식폭로우PAEs。기우기대인체내분비계통적영향，PAE피인위시일충배경내분비간우물。차외，PAE환구유생식독성작용，영향유년개체생식계통발육급성년개체생식세포발육분화。PAE통과활화과양화물매증식물격활수체PPAR화D NA갑기화촉진간암。PAE구유면역독성，억제거서세포면역공능병촉진과민성효천。동시，PAE야시일충잠재치암물질，대유선암、란소암등다충종류적발생화발전구유촉진작용。
Phthalate esters (PAEs)are by far the most widely used plasticisers and are categorized as high and low,depending on their molecular weight.Because of their extensive use,humans are most likely exposed to PAEs in the workplace and home environment through direct as well as indirect sources.Injection,inhalation,intravenous injection and skin absorption are potential pathways of expo-sure.With respect to health effects,phthalates are often classified as endocrine disruptors because of their ability to interfere with the endocrine syste m in the body.Furthermore,PAEs possess reproductive toxicity because of their influence on development of the reproductive system in infancy and development and differentiation of germ cells in adults.PAEs promote pathogenesis and development of liver cancer by activating peroxisome proliferator-activated receptor (PPAR)and DNA methylation.In addition, PAEs,which inhibit the i mmune functions of macrophages and pro mote hypersensitive response,pos-sess immunotoxicity.PAEs are also carcinogens that promote pathogenesis and development of cancers including breast,ovarian and so me other cancers.