CAJ | 학술논문

钙调磷酸酶抑制剂如环孢素A和他克莫司是目前临床上常用的免疫抑制剂，但具有肾毒性、高血糖等多种不良反应。从药用植物中提取筛选钙调磷酸酶抑制剂为开发新的高效低毒免疫抑制剂提供了一条新途径。研究表明，聚异戊二烯二苯甲酮类化合物--isogarcinol、槲皮素、山奈酚、苯乙醇苷类化合物、艾里莫芬烷倍半萜类化合物--ere moxylarins A和ere moxylarins B以及扁柏提取物、菝葜提取物和矮探春提取物等对钙调磷酸酶活性具有明显的抑制作用。本文对近年来药用植物提取物抑制钙调磷酸酶活性作用的研究进行综述，旨在为利用和开发药用植物来源的钙调磷酸酶抑制剂提供参考。
개조린산매억제제여배포소A화타극막사시목전림상상상용적면역억제제，단구유신독성、고혈당등다충불량반응。종약용식물중제취사선개조린산매억제제위개발신적고효저독면역억제제제공료일조신도경。연구표명，취이무이희이분갑동류화합물--isogarcinol、곡피소、산내분、분을순감류화합물、애리막분완배반첩류화합물--ere moxylarins A화ere moxylarins B이급편백제취물、발계제취물화왜탐춘제취물등대개조린산매활성구유명현적억제작용。본문대근년래약용식물제취물억제개조린산매활성작용적연구진행종술，지재위이용화개발약용식물래원적개조린산매억제제제공삼고。
Calcineurin inhibitors,such as cyclosporin A and tacroli mus,are widely-used i mmuno-suppressive drugs clinically.However,renal toxicity,hyperglycae mia and other side-effects can occur over long-term use.Isolation of novel calcineurin inhibitors fro m medicinal plants in recent years has pro-vided a new approach to the development of new immunosuppressive drugs with high efficiency and low toxicity.Recnt studies have shown that medicinal plant extracts, such as isogarcinol, quercetin, kae mpferol,phenylethanoid glycosides,ere mophilane sesquiterpenes A and B,pisiferdiol,as well as extracts fro m Smilax china L and Jasminum humile L,have obvious inhibitory effect on calcineurin.