CAJ | 학술논문

目的：探讨常用无机盐对活化部分凝血酶时间（ aPTT）、凝血酶原时间（ PT）和凝血酶时间（ TT）的影响。方法以不同浓度的NaCl、KCl、NaHCO3、NaH2 PO4为样品测定aPTT、PT和TT。结果四种无机盐能够明显延长aPTT、PT、TT时间，呈现出体外抗凝作用，作用强度与浓度呈正相关。四种盐抗凝能力强弱如下：NaH2 PO4＞NaHCO3＞NaCl＞KCl。结论无机盐会参与到凝血过程，对aPTT、PT和TT产生影响，如果样品中含有无机盐，应考虑到其影响。
목적：탐토상용무궤염대활화부분응혈매시간（ aPTT）、응혈매원시간（ PT）화응혈매시간（ TT）적영향。방법이불동농도적NaCl、KCl、NaHCO3、NaH2 PO4위양품측정aPTT、PT화TT。결과사충무궤염능구명현연장aPTT、PT、TT시간，정현출체외항응작용，작용강도여농도정정상관。사충염항응능력강약여하：NaH2 PO4＞NaHCO3＞NaCl＞KCl。결론무궤염회삼여도응혈과정，대aPTT、PT화TT산생영향，여과양품중함유무궤염，응고필도기영향。
Objective To investigate the effect of commonly used inorganic salts on the determination of activated partial thromboplastin time (aPTT),prothrombin time(PT)and thrombin time(TT).Methods Different concentrations of NaCl ,KCl,NaHCO3 ,NaH2 PO4 were used as samples to measure aPTT ,PT and TT. Results Four kinds of inorganic salt can obviously prolong the time of aPTT ,PT and TT,showing significant anticoagulant effects in vitro .The anticoagulant effect was positively correlated with the concentration and the anticoagulation ability of four tested inorganic salts was as follows:NaH2 PO4 >NaHCO3 >NaCl>KCl.Con-clusion The inorganic salts participated in the coagulation process and affected aPTT ,PT and TT,which should be taken into consideration if the samples contain inorganic salt .