CAJ | 학술논문

目的：探讨联合应用声脉冲辐射力成像技术（ ARFI），血清铁指标（血清铁、铁蛋白），血清肝纤维化四项（ III型前胶原、IV型胶原、层黏蛋白、透明质酸）对诊断肝纤维化与肝硬化的价值。方法根据病理检查结果将81例将患者分为正常组、肝纤维化组、肝硬化组，进行上述7项指标的检测，然后对各组数据进行组间比较，画出各组测量指标的ROC曲线，并得出单一及联合诊断的敏感度、特异度。结果另2组患者与正常组各检验指标（除了III型前胶原）比较差异有统计学意义（ P＜0．01）；联合检测可以提高肝脏疾病诊断的灵敏度，但是特异度有所降低。结论联合应用ARFI技术与血清学肝纤维化4项、血清铁指标测定有助提高肝脏疾病诊断的综合灵敏度，但综合特异度有所降低。
목적：탐토연합응용성맥충복사력성상기술（ ARFI），혈청철지표（혈청철、철단백），혈청간섬유화사항（ III형전효원、IV형효원、층점단백、투명질산）대진단간섬유화여간경화적개치。방법근거병리검사결과장81례장환자분위정상조、간섬유화조、간경화조，진행상술7항지표적검측，연후대각조수거진행조간비교，화출각조측량지표적ROC곡선，병득출단일급연합진단적민감도、특이도。결과령2조환자여정상조각검험지표（제료III형전효원）비교차이유통계학의의（ P＜0．01）；연합검측가이제고간장질병진단적령민도，단시특이도유소강저。결론연합응용ARFI기술여혈청학간섬유화4항、혈청철지표측정유조제고간장질병진단적종합령민도，단종합특이도유소강저。
Objective To discuss the value of acoustic impulse radiation force imaging combined with serum iron indexes ( serum iron and ferritin ) and 4 serum liver fibrosis indexes ( type III collagen , type IV collagen , layer mucin and hyaluronic acid ) in the diagnosis of liver fibrosis and cirrhosis .Methods In accordance with the pathological detection results , 81 patients were divided into the normal control group , the liver fibrosis group and the liver cirrhosis group , and the detection of 7 indices were made according-ly.Then, the obtained data were compared between groups , ROC curves of the detected data of all the groups were plotted , and finally, the sensitivity and specificity of the single and joint diagnosis were derived .Results Statistical significance could be noticed , when the detection data of the 2 patient groups were compared with those of the control group (P<0.01), but type III collagen was an exception . Combined detection could increase the sensitivity of hepatic disease diagnosis , however, specificity was decreased to some extent . Conclusion ARFI technique combined with 4 serological detection of liver fibrosis , serum iron and ferritin could improve comprehen-sive sensitivity of the hepatic disease diagnosis .