CAJ | 학술논문

目的：观察丹红注射液治疗心血瘀阻型不稳定心绞痛（ UA）的临床疗效。方法选择心血瘀阻型UA患者96例，按照数字表法随机分为治疗组和对照组各48例，对照组应用西药常规治疗（抗凝、调脂、扩血管等），治疗组在西药常规治疗基础上加用丹红注射液20 ml/d，2组均连续治疗14 d（1个疗程），于疗程开始前1d和结束后分别观察2组中医证候评分、心绞痛疼痛强度、发作次数及持续时间、静息心电图缺血改变、检测血液流变学及纤维蛋白原（ Fg ）水平等指标。结果2组治疗后中医证候评分、心绞痛疗效、心电图变化、血液流变学及Fg水平较治疗前差异差异有统计学意义（ P＜0．05或＜0．01）。结论丹红注射液治疗心血瘀阻型UA可改善患者中医临床症状、减少心绞痛发作次数及持续时间、降低心绞痛疼痛强度、明显改善心肌缺血，并能降低血液流变学及Fg水平，且无明显不良反应。
목적：관찰단홍주사액치료심혈어조형불은정심교통（ UA）적림상료효。방법선택심혈어조형UA환자96례，안조수자표법수궤분위치료조화대조조각48례，대조조응용서약상규치료（항응、조지、확혈관등），치료조재서약상규치료기출상가용단홍주사액20 ml/d，2조균련속치료14 d（1개료정），우료정개시전1d화결속후분별관찰2조중의증후평분、심교통동통강도、발작차수급지속시간、정식심전도결혈개변、검측혈액류변학급섬유단백원（ Fg ）수평등지표。결과2조치료후중의증후평분、심교통료효、심전도변화、혈액류변학급Fg수평교치료전차이차이유통계학의의（ P＜0．05혹＜0．01）。결론단홍주사액치료심혈어조형UA가개선환자중의림상증상、감소심교통발작차수급지속시간、강저심교통동통강도、명현개선심기결혈，병능강저혈액류변학급Fg수평，차무명현불량반응。
Objective To observe the clinical effect of Danhong injection on blood stasis type unstable angina ( UA ) . Methods Ninety-six blood stasis type UA patients were randomly divided into the treatment group and the control group , each consis-ting of 48 patients.The patients in the control group were treated with routine western medicine (anti-coagulation, lipid regulation, vas-odilation drugs, etc), while the patients in the treatment group were given routine western medicine plus Danhong injection , with a dos-age of 20 ml/d and all were treated for 14 days ( a treatment course ) .Traditional Chinese medicine syndrome scores , angina pain inten-sity, attack frequency and duration , and changes in resting ischemic electrocardiography , hemorheology and fibrinogen ( Fg) level for the two groups were detected , 1 days before the treatment course began and shortly after termination of treatment .Results Following treatment, significant differences could be noted in traditional Chinese medicine syndrome cores , curative effect on angina pectoris , changes in ECG, blood rheological and Fg levels , as compared with those before treatment (P<0.05 or P<0.01).Conclusion Dan-hong injection in the treatment of blood stasis type UA could improve TCM clinical syndromes , reduce attack frequency and duration of angina pectoris , decrease angina pain intensity , improve obviously myocardial ischemia and reduce blood rheology and Fg levels .Fur-thermore, it did not produce obvious adverse reactions .