CAJ | 학술논문

目的观察COPD患者血清IL-6和C反应蛋白(CRP)在3年随访中的变化与预后的关系。方法61例处于COPD稳定期的患者，测定其呼吸功能、血清IL-6和CRP水平、6min步行距离和身体指数作为基线，每年同一时期测定相同指标，跟踪随访3年。结果3年后IL-6水平明显高于基线值的患者(<0.05)的6min步行距离实验表现明显变差(<0.05)；而CRP水平变化不明显(跃0.05)。结论 IL-6水平与COPD患者的预后有明显的相关性。
목적관찰COPD환자혈청IL-6화C반응단백(CRP)재3년수방중적변화여예후적관계。방법61례처우COPD은정기적환자，측정기호흡공능、혈청IL-6화CRP수평、6min보행거리화신체지수작위기선，매년동일시기측정상동지표，근종수방3년。결과3년후IL-6수평명현고우기선치적환자(<0.05)적6min보행거리실험표현명현변차(<0.05)；이CRP수평변화불명현(약0.05)。결론 IL-6수평여COPD환자적예후유명현적상관성。
Objective The purpose of this study was to examine the relation between the concentration of plasma CRP and IL-6 and the prognosis in COPD patients. Methods A cohort of 61 outpatient with stable COPD was evaluated at baseline. We evaluated interleukin-6 (IL-6), -reactive protein (CRP), six-minutes walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Results IL-6 increased significantly after 3 years compared to baseline measurements ( <0.05) and was associated with worse 6MWD performance ( <0.05). CRP mean values did not change ( ﹥0.05) pompared with baseline after 3 years. Conclusion These results indicate that The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients.