CAJ | 학술논문

为研究ns脉冲电场诱导肿瘤细胞的凋亡效应,结合Marx发生器原理和全固态开关技术,研制了一套基于现场可编程门阵列（FPGA）的多参数可调全固态高压ns脉冲发生器。该发生器主要包括高压直流电源、Marx电路、FPGA控制电路和负载4部分。Marx电路采用金属氧化物半导体场效应晶体管（MOSFET）作为控制开关代替传统的火花间隙开关,用二极管代替电阻。FPGA产生多路同步触发脉冲信号,通过光纤进行隔离后可作为MOSFET的原始控制信号,同步驱动多个MOSFET。FPGA控制电路控制充电电压和输出脉冲的宽度、频率,并具有保护功能。实验结果表明,该脉冲发生器可产生幅值（0～8kV）连续可调、脉宽（200～1 000ns）灵活可变、频率（1～1 000Hz）独立可控,前沿35ns的高压ns脉冲,为进一步探索ns脉冲电场生物医学效应奠定了基础。
위연구ns맥충전장유도종류세포적조망효응,결합Marx발생기원리화전고태개관기술,연제료일투기우현장가편정문진렬（FPGA）적다삼수가조전고태고압ns맥충발생기。해발생기주요포괄고압직류전원、Marx전로、FPGA공제전로화부재4부분。Marx전로채용금속양화물반도체장효응정체관（MOSFET）작위공제개관대체전통적화화간극개관,용이겁관대체전조。FPGA산생다로동보촉발맥충신호,통과광섬진행격리후가작위MOSFET적원시공제신호,동보구동다개MOSFET。FPGA공제전로공제충전전압화수출맥충적관도、빈솔,병구유보호공능。실험결과표명,해맥충발생기가산생폭치（0～8kV）련속가조、맥관（200～1 000ns）령활가변、빈솔（1～1 000Hz）독립가공,전연35ns적고압ns맥충,위진일보탐색ns맥충전장생물의학효응전정료기출。
In order to study tumor cell apoptosis induced by nanosecond pulsed electric fields（nsPEF）,we developed a multiple-parameters adjustable total-solid-state high-voltage nanosecond pulse generator using a field programmable gate array（FPGA）.Making use of a combination of Marx principle and all solid-state switching technology,the generator consists of a high-voltage DC power supply,a Marx circuit,a controller using an FPGA.The Marx circuit uses MOSFETs as control switches instead of spark gap,and diodes instead of resistors.The FPGA produces synchronous trigger pulse which is the original control signal of MOSFETs,and is isolated by optical fibers.The FPGA control circuit controls the charge voltage,pulse width and frequency.The function of over-current and short protection is also designed.The experimental results prove that the generator has capability of producing high voltage repetitive pulses with a continually adjustable function with voltage from 0 to 8 kV,pulse width from 200 to 1 000 ns,repetition rate from 1 to 1 000 Hz and rise time of 35 ns.The generator is competent for further exploration of biomedical effects induced by nsPEF.