CAJ | 학술논문

目的探讨丙戊酸钠静脉滴注治疗癫痫持续状态(status epilepticus,SE)的有效性及安全性.方法 60例SE患者随机分为治疗组和对照组各30例,治疗组使用丙戊酸钠注射液,首剂以1 5 mg/kg剂量缓慢静脉推注,推注时间5分钟.然后以1 mg/ (kg.hr)的速度静滴.对照组使用地西泮注射液,首剂以10 mg缓慢静脉推注,推注时间5分钟.随后以地西泮100 mg溶于生理盐水500ml中,于12小时内缓慢静脉滴注.结果两组控制例数差异无统计学意义(P＞0.05).治疗组复发率低于对照组,差异具有统计学意义(P＜0.05).治疗组对呼吸、意识的影响小,差异具有统计学意义(P＜0.05).结论静脉滴注丙戊酸钠治疗SE是一种有效的方法,不良反应少,值得临床推广应用.
목적 탐토병무산납정맥적주치료전간지속상태(status epilepticus,SE)적유효성급안전성.방법 60례SE환자수궤분위치료조화대조조각30례,치료조사용병무산납주사액,수제이1 5 mg/kg제량완만정맥추주,추주시간5분종.연후이1 mg/ (kg.hr)적속도정적.대조조사용지서반주사액,수제이10 mg완만정맥추주,추주시간5분종.수후이지서반100 mg용우생리염수500ml중,우12소시내완만정맥적주.결과 량조공제례수차이무통계학의의(P＞0.05).치료조복발솔저우대조조,차이구유통계학의의(P＜0.05).치료조대호흡、의식적영향소,차이구유통계학의의(P＜0.05).결론 정맥적주병무산납치료SE시일충유효적방법,불량반응소,치득림상추엄응용.
Objective To explore the efficacy and safety of intravenous administration of sodium valproate for epileptic state (SE).Methods 60 patients with SE were randomly divided into a study group and a control group,30 for each group.The study group received a slow intravenous injection of sodium valproate at an initial dose of 15mg/kg for 5 minutes,and then an continuous infusion of 1 mg / (kg.hr) ; while the control group received a slow intravenous injection of diazepam at an initial dose of 10mg for 5 minutes,and then an intravenous drip with mixed solution of diazepam of 100 mg and 0.9％ sodium chloride of 500 ml.Results There was no significant difference between the two groups in control cases (P＞0.05).The recurrent rate was lower in the study group than in the control group,with a significant statistical difference (P＜0.05).Sodium valproate had smaller effects on respiration and consciousness than diazepam,with a significant statistical difference (P＜0.05).Conclusions Intravenous administration of sodium valproste is an effective method in the treatment of epileptic state.It has fewer adverse reactions and is worth popularizing clinically.