国际麻醉学与复苏杂志
國際痳醉學與複囌雜誌
국제마취학여복소잡지
INTERNATIONAL JOURNAL OF ANESTHESIOLOGY AND RESUSCITATION
2014年
5期
462-464,472
,共4页
全身麻醉药物%术后认知功能障碍%γ-氨基丁酸A型受体%突触可塑性%Tau蛋白%细胞凋亡
全身痳醉藥物%術後認知功能障礙%γ-氨基丁痠A型受體%突觸可塑性%Tau蛋白%細胞凋亡
전신마취약물%술후인지공능장애%γ-안기정산A형수체%돌촉가소성%Tau단백%세포조망
General anesthetic%Postoperative cognitive dysfunction%γ-aminobutyrate A receptor%Synaptic plasticity%Tau protein%Apoptosis
背景 研究证实全身麻醉药物对认知功能具有一定的影响,其确切机制目前尚无定论. 目的 综述全身麻醉药物影响术后认知功能的各种可能机制及进展. 内容 全身麻醉药物可能通过影响神经递质及受体、突触可塑性、微管相关蛋白以及细胞凋亡机制对认知功能产生作用. 趋向 探讨全身麻醉药物影响认知功能的机制,为预防和治疗术后认知功能障碍(postoperative cognitive dysfunction,POCD)探索可能方法.
揹景 研究證實全身痳醉藥物對認知功能具有一定的影響,其確切機製目前尚無定論. 目的 綜述全身痳醉藥物影響術後認知功能的各種可能機製及進展. 內容 全身痳醉藥物可能通過影響神經遞質及受體、突觸可塑性、微管相關蛋白以及細胞凋亡機製對認知功能產生作用. 趨嚮 探討全身痳醉藥物影響認知功能的機製,為預防和治療術後認知功能障礙(postoperative cognitive dysfunction,POCD)探索可能方法.
배경 연구증실전신마취약물대인지공능구유일정적영향,기학절궤제목전상무정론. 목적 종술전신마취약물영향술후인지공능적각충가능궤제급진전. 내용 전신마취약물가능통과영향신경체질급수체、돌촉가소성、미관상관단백이급세포조망궤제대인지공능산생작용. 추향 탐토전신마취약물영향인지공능적궤제,위예방화치료술후인지공능장애(postoperative cognitive dysfunction,POCD)탐색가능방법.
Background Although researches have confirmed that general anesthetics could effect on cognitive function,the underlying mechanisms and the contribution of general anaesthesia in particular to postoperative cognitive dysfunction remain unclear.Objective To review the mechanism of general anesthetics induced cognitive dysfunction.Content General anesthetics may intervent cognitive dysfunction through neurotransmitter and its receptor,synaptic plasticity,microtubules related protein and neuroapoptosis.Trend To explore the exact mechanisms of postoperative cognitive dysfunction (POCD),and to find the possible methods for prevention or treatment of POCD.
