实用肝脏病杂志
實用肝髒病雜誌
실용간장병잡지
JOURNAL OF CLINICAL HEPATOLOGY
2013年
6期
508-510
,共3页
邱洁%龙启强%冯艳红%常家宝%戴玮玮%李丽%吴卫峰
邱潔%龍啟彊%馮豔紅%常傢寶%戴瑋瑋%李麗%吳衛峰
구길%룡계강%풍염홍%상가보%대위위%리려%오위봉
急性乙型肝炎%慢性乙型肝炎%NK细胞%T淋巴细胞
急性乙型肝炎%慢性乙型肝炎%NK細胞%T淋巴細胞
급성을형간염%만성을형간염%NK세포%T림파세포
Acute hepatitis B%Chronic hepatitis B%Natural killer cells%T lymphocytes
目的：观察急性和慢性乙型肝炎患者急性期和恢复期外周血NK细胞和T淋巴细胞亚群的变化。方法在40例急性乙型肝炎和40例慢性乙型肝炎患者，分别在急性期和恢复期检测CD3+CD4+T细胞、CD3+CD8+T细胞和NK（CD3-CD16+CD56+）细胞占淋巴细胞的比率（%）。结果在急性乙型肝炎急性期NK细胞计数为（15.7±7.5）%，而在恢复期则上升至（21.9±8.2）%，（P<0.05）；急性乙型肝炎患者在急性期CD3+CD4+T细胞为（35.5±6.8）%，到恢复期则显著下降（33.6±7.0）%，（P<0.05）；急性乙型肝炎在急性期CD3+CD8+T细胞为（35.6±7.6）%，而在恢复期则显著下降（30.0±7.5）%，（P<0.05），后者仍比慢性乙型肝炎患者在病情恢复期高（19.1±7.1）%，（P<0.05）。结论在急性乙型肝炎病程中，NK细胞呈上升趋势，CD3+CD8+T细胞呈下降趋势，而在慢性乙型肝炎患者NK细胞及T淋巴细胞数量下降，致病情迁延不愈。
目的：觀察急性和慢性乙型肝炎患者急性期和恢複期外週血NK細胞和T淋巴細胞亞群的變化。方法在40例急性乙型肝炎和40例慢性乙型肝炎患者，分彆在急性期和恢複期檢測CD3+CD4+T細胞、CD3+CD8+T細胞和NK（CD3-CD16+CD56+）細胞佔淋巴細胞的比率（%）。結果在急性乙型肝炎急性期NK細胞計數為（15.7±7.5）%，而在恢複期則上升至（21.9±8.2）%，（P<0.05）；急性乙型肝炎患者在急性期CD3+CD4+T細胞為（35.5±6.8）%，到恢複期則顯著下降（33.6±7.0）%，（P<0.05）；急性乙型肝炎在急性期CD3+CD8+T細胞為（35.6±7.6）%，而在恢複期則顯著下降（30.0±7.5）%，（P<0.05），後者仍比慢性乙型肝炎患者在病情恢複期高（19.1±7.1）%，（P<0.05）。結論在急性乙型肝炎病程中，NK細胞呈上升趨勢，CD3+CD8+T細胞呈下降趨勢，而在慢性乙型肝炎患者NK細胞及T淋巴細胞數量下降，緻病情遷延不愈。
목적：관찰급성화만성을형간염환자급성기화회복기외주혈NK세포화T림파세포아군적변화。방법재40례급성을형간염화40례만성을형간염환자，분별재급성기화회복기검측CD3+CD4+T세포、CD3+CD8+T세포화NK（CD3-CD16+CD56+）세포점림파세포적비솔（%）。결과재급성을형간염급성기NK세포계수위（15.7±7.5）%，이재회복기칙상승지（21.9±8.2）%，（P<0.05）；급성을형간염환자재급성기CD3+CD4+T세포위（35.5±6.8）%，도회복기칙현저하강（33.6±7.0）%，（P<0.05）；급성을형간염재급성기CD3+CD8+T세포위（35.6±7.6）%，이재회복기칙현저하강（30.0±7.5）%，（P<0.05），후자잉비만성을형간염환자재병정회복기고（19.1±7.1）%，（P<0.05）。결론재급성을형간염병정중，NK세포정상승추세，CD3+CD8+T세포정하강추세，이재만성을형간염환자NK세포급T림파세포수량하강，치병정천연불유。
Objective To investigate the changes of natural killer (NK)cell and T lymphocyte counts in pa-tients with acute hepatitis B and with chronic hepatitis B. Methods The percentages of CD3+CD4+ T lymphocytes, the CD3+CD8+ T lymphocytes and CD3-CD16+CD56+(NK)cells in peripheral blood of 40 patients with acute hepatitis B and 40 patients with chronic hepatitis B were detected by flow cytometry. Results The percentages of NK cells in acute stage of patients with acute hepatitis B were (15.7±7.5)%,which increased to (21.9±8.2)%,(P<0.05)in convalescent stage;the percentages of CD3+CD4+T cells in acute stage of patients with acute hepatitis B were(35.5± 6.8)%,which decreased to(33.6±7.0)%,(P<0.05)in convalescent stage;the percentages of CD3+CD8+T cells in acute stage of patients with acute hepatitis B were (35.6±7.6)%,which decreased to(30.0±7.5)%,(P<0.05)in convales-cent stage,and which were still higher than that (19.1 ±7.1)%,(P<0.05)in convalescent stage of patients with chronic hepatitis B. Conclusions The percentages of NK cells has a rising,while the percentages of CD3+CD8+T lymphocytes has a decreasing tendency in the course of acute hepatitis B;The percentages of NK cells and T lym-phocytes in peripheral blood of patients with chronic hepatitis B decrease,which might be related to the chronicity of the diseases.
