实用肝脏病杂志
實用肝髒病雜誌
실용간장병잡지
JOURNAL OF CLINICAL HEPATOLOGY
2013年
6期
499-501
,共3页
王军%魏艳玲%范丽玲%肖潇%颜綦先%李娅%陈东风
王軍%魏豔玲%範麗玲%肖瀟%顏綦先%李婭%陳東風
왕군%위염령%범려령%초소%안기선%리아%진동풍
非酒精性脂肪性肝病%心血管疾病%内皮功能%粥样硬化
非酒精性脂肪性肝病%心血管疾病%內皮功能%粥樣硬化
비주정성지방성간병%심혈관질병%내피공능%죽양경화
Nonalcoholic fatty liver disease%Cardiovascular disease%Endothelial function%Atherosclerosis
目的：探讨非酒精性脂肪性肝病（NAFLD)与心血管疾病（CVD）的关系。方法根据CT检查结果将研究对象分为NAFLD患者（48例）和健康人（43例），超声测定外周血管硬化和颈动脉内膜中层厚度（IMT）等相关指标，检测生化和内皮舒张功能指标，心脏CTA检测冠状动脉粥样病变。结果 NAFLD患者可溶性细胞间黏附分子-1[sICM-1，（185.1±36.2）ng/ml]、血内皮素-1[ET-1，（104.8±19.3）pg/ml]和臂踝脉搏波速度[baPWV，（15.5±2.3） cm/s]显著高于健康人（85.4±17.3）ng/ml、（67.5±12.1）pg/ml和（13.6±2.4）cm/s，（P<0.05），而肱动脉血流介导的内皮依赖性舒张功能[FMD，（8.1±2.4）%]明显低于健康人（13.2±3.5）%，（P<0.05）；此外，NAFLD患者颈动脉IMT厚度（1.31±0.35）mm、劲动脉（31.3%）和冠状动脉粥样斑块检出率（35.4%）均明显高于对照组（0.76±0.18）mm、9.3%和11.6%，（P<0.05）；Pearson相关分析显示NAFLD分别与IMT、劲动脉和冠状动脉粥样斑块检出率显著正相关（P<0.01）。结论 NAFLD与CVD密切相关，NAFLD患者可能存在血管内皮功能障碍，应定期进行IMT和粥样斑块检测。
目的：探討非酒精性脂肪性肝病（NAFLD)與心血管疾病（CVD）的關繫。方法根據CT檢查結果將研究對象分為NAFLD患者（48例）和健康人（43例），超聲測定外週血管硬化和頸動脈內膜中層厚度（IMT）等相關指標，檢測生化和內皮舒張功能指標，心髒CTA檢測冠狀動脈粥樣病變。結果 NAFLD患者可溶性細胞間黏附分子-1[sICM-1，（185.1±36.2）ng/ml]、血內皮素-1[ET-1，（104.8±19.3）pg/ml]和臂踝脈搏波速度[baPWV，（15.5±2.3） cm/s]顯著高于健康人（85.4±17.3）ng/ml、（67.5±12.1）pg/ml和（13.6±2.4）cm/s，（P<0.05），而肱動脈血流介導的內皮依賴性舒張功能[FMD，（8.1±2.4）%]明顯低于健康人（13.2±3.5）%，（P<0.05）；此外，NAFLD患者頸動脈IMT厚度（1.31±0.35）mm、勁動脈（31.3%）和冠狀動脈粥樣斑塊檢齣率（35.4%）均明顯高于對照組（0.76±0.18）mm、9.3%和11.6%，（P<0.05）；Pearson相關分析顯示NAFLD分彆與IMT、勁動脈和冠狀動脈粥樣斑塊檢齣率顯著正相關（P<0.01）。結論 NAFLD與CVD密切相關，NAFLD患者可能存在血管內皮功能障礙，應定期進行IMT和粥樣斑塊檢測。
목적：탐토비주정성지방성간병（NAFLD)여심혈관질병（CVD）적관계。방법근거CT검사결과장연구대상분위NAFLD환자（48례）화건강인（43례），초성측정외주혈관경화화경동맥내막중층후도（IMT）등상관지표，검측생화화내피서장공능지표，심장CTA검측관상동맥죽양병변。결과 NAFLD환자가용성세포간점부분자-1[sICM-1，（185.1±36.2）ng/ml]、혈내피소-1[ET-1，（104.8±19.3）pg/ml]화비과맥박파속도[baPWV，（15.5±2.3） cm/s]현저고우건강인（85.4±17.3）ng/ml、（67.5±12.1）pg/ml화（13.6±2.4）cm/s，（P<0.05），이굉동맥혈류개도적내피의뢰성서장공능[FMD，（8.1±2.4）%]명현저우건강인（13.2±3.5）%，（P<0.05）；차외，NAFLD환자경동맥IMT후도（1.31±0.35）mm、경동맥（31.3%）화관상동맥죽양반괴검출솔（35.4%）균명현고우대조조（0.76±0.18）mm、9.3%화11.6%，（P<0.05）；Pearson상관분석현시NAFLD분별여IMT、경동맥화관상동맥죽양반괴검출솔현저정상관（P<0.01）。결론 NAFLD여CVD밀절상관，NAFLD환자가능존재혈관내피공능장애，응정기진행IMT화죽양반괴검측。
Objective To investigate the risk factors of cardiovascular disease in patients with nonalcoholic fatty liver disease (NAFLD). Methods Forty-eight patients with NAFLD and forty-three healthy persons were in-cluded in this study. The NAFLD was diagnosed by computed tomography. Ultrasound was taken for intimal medi-al thickness (IMT)and carotid atherosclerotic plaque examination. The clinical and biochemical features,endothelial function and coronary atherosclerotic plaque examination were also analyzed. Results The levels of sICM-1,ET-1 and baPWV in NAFLD group(185.1±36.2)ng/ml,(104.8±19.3)pg/ml and(15.5±2.3)cm/s were higher than those (85.4±17.3)ng/ml,(67.5±12.1)pg/ml and (13.6±2.4)cm/s,(P<0.05),while the FMD level (8.1±2.4)%was lower than that (13.2±3.5%),(P<0.05)in the healthy persons;In addition,the IMT (1.31±0.35)mmand the prevalence of patches in carotid(31.3%)and in coronary artery(35.4%)in patients with NAFLD increased than in healthy per-sons (0.76±0.18)mm,9.3% and 11.6%,(P<0.05). Conclusion NAFLD is closely associated with cardiovascular disease. The patients with NAFLD might have vascular endothelial dysfunction,and they might be checked-up for early evaluation of vascular atherosclerosis.
