中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2014年
2期
187-188,191
,共3页
牛晓红%李俊岩%宋祺%金苗苗%刘金霞
牛曉紅%李俊巖%宋祺%金苗苗%劉金霞
우효홍%리준암%송기%금묘묘%류금하
糖尿病,2型%近亲%葡糖耐量试验%白细胞介素6/血液%C反应蛋白质/血液%胰岛素抗药性
糖尿病,2型%近親%葡糖耐量試驗%白細胞介素6/血液%C反應蛋白質/血液%胰島素抗藥性
당뇨병,2형%근친%포당내량시험%백세포개소6/혈액%C반응단백질/혈액%이도소항약성
Diabetes mellitus,type 2%Consanguinity%Glucose tolerance test%Interleukin-6/blood%C-reactive protein/blood%Insulin resistance
目的：探讨血IL-6、超敏C反应蛋白（hs-CRP）在2型糖尿病中的作用。方法测定2型糖尿病（T2DM）患者糖耐量正常的一级亲属（NGT）136例及无糖尿病家族史的正常对照（NC）82例血糖、糖化血红蛋白（HbA1c）、血脂、胰岛素、IL-6、hs-CRP水平，并进行比较分析。结果⑴NGT组与NC组相比，胰岛素抵抗指数（ HOMA-IR）、hs-CRP、IL-6明显升高[分别是1.03～1.94 vs 0.42～0.95， P ＜0.01；0.46～2.78 mg／L vs 0.39～1.56 mg／L， P ＜0.01；（13.6±8.99）pg／ml vs （8.08±3.67）pg／ml， P ＜0.01]。⑵T2DM患者一级亲属中血hs-CRP水平与HOMA-IR（ r ＝0.326， P ＜0.01）、IL-6（ r ＝0.258， P ＜0.05）均呈正相关；T2DM患者一级亲属中血IL-6水平与HOMA-IR呈正相关（ r ＝0.350， P ＜0.01）。结论血清CRP和IL-6可能与T2DM患者一级亲属的胰岛素抵抗密切相关。
目的：探討血IL-6、超敏C反應蛋白（hs-CRP）在2型糖尿病中的作用。方法測定2型糖尿病（T2DM）患者糖耐量正常的一級親屬（NGT）136例及無糖尿病傢族史的正常對照（NC）82例血糖、糖化血紅蛋白（HbA1c）、血脂、胰島素、IL-6、hs-CRP水平，併進行比較分析。結果⑴NGT組與NC組相比，胰島素牴抗指數（ HOMA-IR）、hs-CRP、IL-6明顯升高[分彆是1.03～1.94 vs 0.42～0.95， P ＜0.01；0.46～2.78 mg／L vs 0.39～1.56 mg／L， P ＜0.01；（13.6±8.99）pg／ml vs （8.08±3.67）pg／ml， P ＜0.01]。⑵T2DM患者一級親屬中血hs-CRP水平與HOMA-IR（ r ＝0.326， P ＜0.01）、IL-6（ r ＝0.258， P ＜0.05）均呈正相關；T2DM患者一級親屬中血IL-6水平與HOMA-IR呈正相關（ r ＝0.350， P ＜0.01）。結論血清CRP和IL-6可能與T2DM患者一級親屬的胰島素牴抗密切相關。
목적：탐토혈IL-6、초민C반응단백（hs-CRP）재2형당뇨병중적작용。방법측정2형당뇨병（T2DM）환자당내량정상적일급친속（NGT）136례급무당뇨병가족사적정상대조（NC）82례혈당、당화혈홍단백（HbA1c）、혈지、이도소、IL-6、hs-CRP수평，병진행비교분석。결과⑴NGT조여NC조상비，이도소저항지수（ HOMA-IR）、hs-CRP、IL-6명현승고[분별시1.03～1.94 vs 0.42～0.95， P ＜0.01；0.46～2.78 mg／L vs 0.39～1.56 mg／L， P ＜0.01；（13.6±8.99）pg／ml vs （8.08±3.67）pg／ml， P ＜0.01]。⑵T2DM환자일급친속중혈hs-CRP수평여HOMA-IR（ r ＝0.326， P ＜0.01）、IL-6（ r ＝0.258， P ＜0.05）균정정상관；T2DM환자일급친속중혈IL-6수평여HOMA-IR정정상관（ r ＝0.350， P ＜0.01）。결론혈청CRP화IL-6가능여T2DM환자일급친속적이도소저항밀절상관。
Objective To study the relationship of the levels of serum interleukin-6 (IL-6) and C-reactive protein (CRP) with insulin resistance in normal glucose tolerant first-degree relatives (NGT) of type 2 diabetics.Methods A total of 218 normal glucose tolerance subjects , including 136 NGT of type 2 diabetes , and 82 normal control ( NC) without type 2 diabetes family history were enrolled.The levels of blood glucose, hemoglobin A1c (HbA1c), lipid, insulin, IL-6, and high-sensitivity C-reactive protein (hs-CRP) were measured.Results ⑴Compared with NC, the levels of homeostasis model assessment of insulin resistance (HOMA-IR), hs-CRP , and IL-6 in NGT were significantly increased [1.03~1.94 vs 0.42~0.95 , P <0.01;0.46~2.78 mg/L vs 0.39~1.56 mg/L, P <0.01;(13.6 ±8.99) pg/ml vs (8.08 ±3.67) pg/ml, P <0.01];⑵In NGT, hs-CRP was positively correlated with HOMA-IR and IL-6 ( r =0.326 , P <0.01;r =0.258 , P <0.05 );IL-6 was positively correlated with HOMA-IR ( r =0.350 , P <0.01).Conclusions IL-6 and CRP may correlate with the degree of insulin resistance in NGT of type 2 diabetics.
