CAJ | 학술논문

目的：探讨先兆性偏头痛、无先兆性偏头痛患者和正常人卵圆孔未闭（ PFO）发生率的差异。方法采用经颅多普勒超声（TCD）检测先兆性偏头痛组（29例）、无先兆偏头痛组（31例）和正常对照组（26名） PFO的发生率，比较各组差异。记录治疗前偏头痛患者的头痛频率、头痛发作日数和头痛程度等，并分析其与PFD分流量大小的相关性。结果先兆性偏头痛组、无先兆偏头痛组和正常对照组PFO发生率分别为72％、45％和31％，先兆偏头痛组PFO发生率较正常对照组高（ P＝0.008），无先兆偏头痛组较正常对照组高，但比较差异尚无统计学意义（ P＝0.491）；PFO大小与头痛频率、头痛发作日数呈正相关（P均＜0.05）。结论先兆偏头痛患者的PFO发生率较高，提示此两种疾病可能有共同的病理学发病机制。
목적：탐토선조성편두통、무선조성편두통환자화정상인란원공미폐（ PFO）발생솔적차이。방법채용경로다보륵초성（TCD）검측선조성편두통조（29례）、무선조편두통조（31례）화정상대조조（26명） PFO적발생솔，비교각조차이。기록치료전편두통환자적두통빈솔、두통발작일수화두통정도등，병분석기여PFD분류량대소적상관성。결과선조성편두통조、무선조편두통조화정상대조조PFO발생솔분별위72％、45％화31％，선조편두통조PFO발생솔교정상대조조고（ P＝0.008），무선조편두통조교정상대조조고，단비교차이상무통계학의의（ P＝0.491）；PFO대소여두통빈솔、두통발작일수정정상관（P균＜0.05）。결론선조편두통환자적PFO발생솔교고，제시차량충질병가능유공동적병이학발병궤제。
Objective To explore the difference in prevalence of patent foramen ovale ( PFO) be-tween migraine patients ( with or without aura ) and healthy person without migraine.Methods Transcranial doppler was used to assess the prevalence of PFO in migraine with aura group ( 29 cases ) , migraine without aura group (31 cases) and healthy-control group (26 cases), compared the difference among the groups.The headache frequency , the headache days and the degree of headache before treatment in migraine patients were recorded , their correlation with the shunt size of PFO were analyzed.Results The prevalence of PFO were 72%, 45%and 31%in migraine with aura group , migraine without aura group and healthy-control group , re-spectively.The difference between migraine with aura group and healthy-control group was statistically signifi-cant (P=0.008).The headache frequency and the headache days positively related with the shunt size of PFO ( P<0.05 ).Conclusion The higher prevalence of PFO in migraine with aura could prompt the common pathogenesis between these two diseases.