CAJ | 학술논문

抑癌基因PTEN的表达缺失多见于包括前列腺癌在内的多种散发性肿瘤，对其抑癌机制以及表达缺失所导致的肿瘤发生发展机理的研究，将为前列腺癌的诊断、治疗以及预后判断提供指导。就PTEN基因的结构、作用机制、表达缺失及其与前列腺癌发病相关的研究进展作一综述。
억암기인PTEN적표체결실다견우포괄전렬선암재내적다충산발성종류，대기억암궤제이급표체결실소도치적종류발생발전궤리적연구，장위전렬선암적진단、치료이급예후판단제공지도。취PTEN기인적결구、작용궤제、표체결실급기여전렬선암발병상관적연구진전작일종술。
The deletion of tumor suppressor gene PTEN's expression was familiar in many tumors, including prostate cancer. The guide would be given in the diagnosis, therapy and prognosis of prostate cancer by studying about PTEN's tumor suppression mechanism and relation with expression deletion. This review makes an overview focusing on the recent progress of PTEN's structure, function, expression deletion, and the correlation between PTEN and prostate cancer.