CAJ | 학술논문

目的：研究纳洛酮联合依达拉奉对急性酒精中毒的临床疗效分析．方法选择急性酒精中毒患者125例，随机分为对照组和治疗组．对照组采取常规治疗及纳洛酮治疗，治疗组在此基础上采用依达拉奉治疗．治疗前及经治疗后分别记录两组清醒时间、呼吸频率恢复时间及症状消失时间、检测两组患者的丙二醛（MDA）、超氧化物歧化酶（SOD）、谷胱甘肽（GSH）、神经元特异性烯醇化酶（NSE）、S-100β及血管细胞黏附分-1（VCAM-1）．结果治疗后治疗组清醒时间及、呼吸频率恢复时间、呼吸频率恢复时间较对照组显著缩短（＜0.05）．对照组治疗后S-100β对治疗前有显著性改善（＜0.05），治疗组治疗后NSE、S-100β、VCAM-1较治疗前均出现显著性下降（＜0.05），S-100β、VCAM-1较对照组差异有统计学意义（＜0.05）．治疗组治疗后MDA较治疗前有显著下降且较对照组差异有统计学意义（＜0.05），SOD、GSH较治疗前有显著性升高且较对照组有显著性差异（＜0.05）．结论纳洛酮及依达拉奉联合用药可以改善急性酒精中毒患者体内氧化应激状态及神经损伤，有助于该类患者早期康复．
목적：연구납락동연합의체랍봉대급성주정중독적림상료효분석．방법선택급성주정중독환자125례，수궤분위대조조화치료조．대조조채취상규치료급납락동치료，치료조재차기출상채용의체랍봉치료．치료전급경치료후분별기록량조청성시간、호흡빈솔회복시간급증상소실시간、검측량조환자적병이철（MDA）、초양화물기화매（SOD）、곡광감태（GSH）、신경원특이성희순화매（NSE）、S-100β급혈관세포점부분-1（VCAM-1）．결과치료후치료조청성시간급、호흡빈솔회복시간、호흡빈솔회복시간교대조조현저축단（＜0.05）．대조조치료후S-100β대치료전유현저성개선（＜0.05），치료조치료후NSE、S-100β、VCAM-1교치료전균출현현저성하강（＜0.05），S-100β、VCAM-1교대조조차이유통계학의의（＜0.05）．치료조치료후MDA교치료전유현저하강차교대조조차이유통계학의의（＜0.05），SOD、GSH교치료전유현저성승고차교대조조유현저성차이（＜0.05）．결론납락동급의체랍봉연합용약가이개선급성주정중독환자체내양화응격상태급신경손상，유조우해류환자조기강복．
Objective To study the clinical efficacy of naloxone combined with edaravone on acute alcoholism. Methods One hundred and twenty-five patients with acute alcoholism were randomly divided into the control and treatment groups. The control group accepted conventional treatment and taking naloxone, while the treatment group accepted edaravone on the basis. Before and after treatment,the treatment recovery time,recovery respiratory rate time and symptom disappearance time were recorded. The malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), neuron-specific enolase (NSE), S-100βand vascular cell adhesion points-1 (VCAM-1) were detected. Results After treatment,the recovery time and recovery respiratory rate time of the treatment group were significantly shorter than those of the control group ( <0.05) . In the control group, S-100β was significantly improved after treatment ( <0.05) . NSE, S-100β, VCAM-1 and MDA have significantly decreased ( <0.05) after treatment in the treatment group. Compared with the control group, there were significant differences of S-100β,VCAM-1 and MDA in the treatment group before and after treatment (<0.05) . While SOD and GSH have significantly increased ( <0.05) after treatment and showed significant differences compared with the control group ( <0.05) . Conclusion Naloxone and edaravone combination therapy can improve oxidative stress and nerve damage, which help early rehabilitation in patients with acute alcoholism.