CAJ | 학술논문

目的：初步探讨脑胶质瘤X线修复交叉互补基因1（XRCC1）的表达与不同级别脑胶质瘤及放疗的关系．方法将26例脑胶质瘤标本分为4组，经免疫组化染色后，观察XRCC1的表达部位和程度．结果 XR-CC1在脑胶质瘤中的表达呈棕黄色粗大颗粒，定位于细胞核内，阳性细胞散在或局灶性分布，染色强度及分布无明显规律．不同级别胶质瘤的XRCC1阳性表达无显著性差异（＞0.05）．结论 XRCC1的表达与脑胶质瘤的病理分级无明显相关性，测定XRCC1的表达水平可为胶质瘤的个性化放射治疗提供部分参考依据．
목적：초보탐토뇌효질류X선수복교차호보기인1（XRCC1）적표체여불동급별뇌효질류급방료적관계．방법장26례뇌효질류표본분위4조，경면역조화염색후，관찰XRCC1적표체부위화정도．결과 XR-CC1재뇌효질류중적표체정종황색조대과립，정위우세포핵내，양성세포산재혹국조성분포，염색강도급분포무명현규률．불동급별효질류적XRCC1양성표체무현저성차이（＞0.05）．결론 XRCC1적표체여뇌효질류적병리분급무명현상관성，측정XRCC1적표체수평가위효질류적개성화방사치료제공부분삼고의거．
Objective To explore the relationship between the expression of XRCC1 and glioma. Methods Total of 26 samples of glioma were divided into 4 groups:gradeⅠ,gradeⅡ,gradeⅢand gradeⅣ. The expression of XRCC1 in 26 Gliomas tissues were examined using SP immunohistochemical staining.Results The positive staining of XRCC1 protein was localized in nucleus of tumor cells in Glioma. There was no correlation among them. The difference of XRCC1 expression among gradeⅠ~Ⅳ was not significant ( >0.05) .Conclusion The difference of XRCC1 expression among gradeⅠ~Ⅳ was not significant. The expression of XRCC1 was closely correlated with the effect of radiotherapy.