CAJ | 학술논문

目的：探讨两种动态动脉硬化指数与早期肾损害征象间的相关性．方法选取原发性高血压患者300例，利用动态血压参数计算对称动态动脉硬化指数（S-AASI）、动态动脉硬化指数（AASI），检测尿微量白蛋白（mA1b）、尿 N-乙酰-β-D-氨基葡萄糖苷酶（NAG），计算肌酐清除率（Ccr）和评估肾小球滤过率（eGFR）．行S-AASI、AASI与早期肾损害指标间的Pearson相关回归分析．结果 S-AASI与尿mA1b （0.708，＜0.01）、NAG （0.700，＜0.01）、sCr （0.229，＜0.05）呈正相关，与 eGFR （-0.309，＜0.05）、Ccr （-0.601，＜0.01）呈负相关．AASI与尿mA1b （0.489，＜0.01）、NAG （0.470，＜0.01）、Ccr （-0.311，＜0.05）相关性也有统计学意义．但与sCr （0.064，＞0.05）和eGFR （-0.135，＞0.05）不相关．结论两种动态动脉硬化指数与早期肾脏损伤相关，S-AASI可能是比AASI更灵敏的一种检测指标．
목적：탐토량충동태동맥경화지수여조기신손해정상간적상관성．방법선취원발성고혈압환자300례，이용동태혈압삼수계산대칭동태동맥경화지수（S-AASI）、동태동맥경화지수（AASI），검측뇨미량백단백（mA1b）、뇨 N-을선-β-D-안기포도당감매（NAG），계산기항청제솔（Ccr）화평고신소구려과솔（eGFR）．행S-AASI、AASI여조기신손해지표간적Pearson상관회귀분석．결과 S-AASI여뇨mA1b （0.708，＜0.01）、NAG （0.700，＜0.01）、sCr （0.229，＜0.05）정정상관，여 eGFR （-0.309，＜0.05）、Ccr （-0.601，＜0.01）정부상관．AASI여뇨mA1b （0.489，＜0.01）、NAG （0.470，＜0.01）、Ccr （-0.311，＜0.05）상관성야유통계학의의．단여sCr （0.064，＞0.05）화eGFR （-0.135，＞0.05）불상관．결론량충동태동맥경화지수여조기신장손상상관，S-AASI가능시비AASI경령민적일충검측지표．
Objective To investigate the relationship between the different ambulatory arterial stiffness index and the markers of renal impairment in order to provide a scientific method for detecting the renal impairment of essential hypertension. Methods Three hundred essential hypertensive patients without overt proteinuria were enrolled. The ABPM was performed and the blood pressure parameters were analyzed in order to estimate the symmetrical ambulatory arterial stiffness index (S-AASI) and ambulatory arterial stiffness index (AASI) . Microproteinuria was measured by urine microalbumin to creatinine (mAlb/Cr)as well as n-acetyl-β-D-glucosaminidase (NAG)to creatinine rate (NAG/Cr). Creatinine clearance (Ccr) and Glomerular filtration rate (eGFR) were estimated from serum creatinine (sCr) . Linear correlations were performed to confirm the independent predictive power of S-AASI and AASI for renal lesion. Results Correlation test showed a significant positively relationship of S-AASI with urine mAlb/Cr (0.708, <0.001), urine NAG/Cr (0.700, <0.001) and sCr (0.229, <0.05) . Ccr (0.601, <0.001) and eGFR (0.309, <0.05) were negatively correlated with S-AASI. On the other hand, AASI was also correlated with urine mAlb/Cr (0.489, <0.001),urine NAG/Cr (0.470, <0.001) and Ccr (0.311, <0.05),but not with the sCr (0.064, >0.05) and eGFR (-0.135, >0.05) . S-AASI seems to get an independent relationship with all of the parameters of renal impairment which could not be detected with AASI. Conclusion This results suggested that S-AASI may be a better approach than AASI to estimate hypertensive renal impairment.