CAJ | 학술논문

目的：调查一起食源性停乳链球菌类马亚型(streptococcus dysgalactiae subspecies equisimilis，SDSE)暴发感染，为快速诊治SDSE感染暴发积累经验。方法采集和分析驻京某部队2012年9月30日-10月1日暴发呼吸道感染70例患者的流行病学资料、症状、体征，对比治疗前后实验室检查结果，进行流行病学和统计学分析。结果70例患者中，表现为发热66例(94.29%)，咽痛62例(88.57%)、扁桃体化脓36例(51.43%)。其中38例(54.29%)咽拭子病原学培养结果为SDSE。患者治疗前后，白细胞计数(white blood cell count，WBC)、中性粒细胞比例(neutropenia leukocyte percent，N%)、C-反应蛋白(C-reactive protein，CRP)、白细胞介素-6(interleukin-6，IL-6)水平差异有统计学意义(P＜0.01)，降钙素原(procalcitonin， PCT)阳性率差异无统计学意义(P＞0.05)。结论食源性SDSE致人群呼吸道暴发感染比较罕见，病原学分离鉴定是关键，血常规和IL-6检测是较好的辅助检查和病情监测方法。
목적：조사일기식원성정유련구균류마아형(streptococcus dysgalactiae subspecies equisimilis，SDSE)폭발감염，위쾌속진치SDSE감염폭발적루경험。방법채집화분석주경모부대2012년9월30일-10월1일폭발호흡도감염70례환자적류행병학자료、증상、체정，대비치료전후실험실검사결과，진행류행병학화통계학분석。결과70례환자중，표현위발열66례(94.29%)，인통62례(88.57%)、편도체화농36례(51.43%)。기중38례(54.29%)인식자병원학배양결과위SDSE。환자치료전후，백세포계수(white blood cell count，WBC)、중성립세포비례(neutropenia leukocyte percent，N%)、C-반응단백(C-reactive protein，CRP)、백세포개소-6(interleukin-6，IL-6)수평차이유통계학의의(P＜0.01)，강개소원(procalcitonin， PCT)양성솔차이무통계학의의(P＞0.05)。결론식원성SDSE치인군호흡도폭발감염비교한견，병원학분리감정시관건，혈상규화IL-6검측시교호적보조검사화병정감측방법。
Objective To accumulate experience with the rapid diagnosis of infection with food-contaminated streptococcus dysgalactiae subspecies equisimilis (SDSE) during its outbreak.Methods Epidemiology data, symptoms, and signs of 70 patients with respiratory tract infection in a certain Chinese PLA unit stationed in Beijing during its outbreak from September 30, 2012 to October 1, 2012 were analyzed.Results Of the 70 patients, 66 (94.29%) were manifested as fever, 62 (88.57%) as sore throat, 36 (51.43%) as tonsillitis, and 38 (54.29%) were diagnosed with SDSE infection according to the cultured pharynx secretion. The number of white blood cells and neutrophils, the serum CRP and IL-6 levels were significantly lower after treatment than before treatment (P<0.01). However, no significant difference was found in serum procalcitonin level before and after treatment (P>0.05). Conclusion Respiratory tract infection with food-contaminated SDSE seldom occurs during its outbreak. Isolation and identification of SDSE are the key to its rapid diagnosis. Routine blood examination and serum IL-6 testing are the effective accessory examination and disease-monitoring methods.