CAJ | 학술논문

目的：比较不明原因发热(fever of unknown origin，FUO)中不同发热时间的病因分布。方法回顾性分析本院发热疾病科2009年10月-2012年12月间所有符合FUO诊断标准的患者临床资料，依据发热时间分为≥21 d和≥30 d两组进行比较。结果本研究共纳入444例患者，其中感染性疾病215例(48.4%)、结缔组织病92例(20.7%)、恶性肿瘤19例(4.3%)、杂病类35例(7.9%)，最终仍有83例(18.7%)未能明确诊断。≥30 d组与≥21 d组相比，FUO病因分布相似，但感染性疾病比例下降(P=0.0254)，其中上呼吸道感染比例减少(P=0.0193)。结论发热时间≥30 d并没有改变FUO病因分布，同时又将一部分具有自愈倾向的上呼吸道感染剔除在外，具有较好的临床意义。
목적：비교불명원인발열(fever of unknown origin，FUO)중불동발열시간적병인분포。방법회고성분석본원발열질병과2009년10월-2012년12월간소유부합FUO진단표준적환자림상자료，의거발열시간분위≥21 d화≥30 d량조진행비교。결과본연구공납입444례환자，기중감염성질병215례(48.4%)、결체조직병92례(20.7%)、악성종류19례(4.3%)、잡병류35례(7.9%)，최종잉유83례(18.7%)미능명학진단。≥30 d조여≥21 d조상비，FUO병인분포상사，단감염성질병비례하강(P=0.0254)，기중상호흡도감염비례감소(P=0.0193)。결론발열시간≥30 d병몰유개변FUO병인분포，동시우장일부분구유자유경향적상호흡도감염척제재외，구유교호적림상의의。
Objective To compare the distribution of causes of fever of unknown origin (FUO) in its different courses.MethodsClinical data about FUO patients admitted to our department from October 2009 to December 2012 were retrospectively analyzed. The patients were divided into group A with its course of fever≥21 days and group B with its course of fever≥30 days.Results Of the 444 FUO patients enrolled in this study, 215 (48.4%) were diagnosed with infectious diseases, 92 (20.7%) were diagnosed with connective tissue diseases, 19 (4.3%) were diagnosed with tumors, 35 (7.9%) were diagnosed with miscellaneous diseases, and 83 (18.7%) were not clearly diagnosed. The distribution of causes of FUO was similar in group A with its course of fever≥21 days and group B with its course of fever≥30 days. The incidence of infectious diseases, especially upper respiratory tract infectious diseases, was significantly lower in group B with its course of fever≥30 days than in group A with its course of fever≥21days (P= 0.025 4, P= 0.019 3).Conclusion No change occurs in the distribution of causes of FUO in FUO patients with their course of FUO≥30 days, which is of certain clinical significance when upper respiratory tract infectious diseases with a tendency to cure are excluded.