CAJ | 학술논문

目的：对CD4+CD25+CD127-调节性T细胞与分娩发动的关系进行初步探索。方法选择40例孕妇，分别检测其36孕周、37孕周、38孕周、39孕周及临产时静脉血调节性T细胞比例及宫颈成熟度，同时检测22例过期妊娠孕妇及50例已婚未孕正常女性的外周静脉血调节性T细胞比例，分析调节性T细胞比例与宫颈成熟度的关系。结果孕36周至临产期间孕妇调节性T细胞比例大于正常未孕女性；随着孕周的增加调节性T细胞比例逐渐下降，由孕36周时的9.09%下降至临产时的5.48%，宫颈Bishop评分逐渐升高，调节性T细胞比例与宫颈成熟度成直线反向相关；过期妊娠孕妇调节性T细胞比例小于临产产妇。结论调节性T细胞与分娩发动有关。
목적：대CD4+CD25+CD127-조절성T세포여분면발동적관계진행초보탐색。방법선택40례잉부，분별검측기36잉주、37잉주、38잉주、39잉주급임산시정맥혈조절성T세포비례급궁경성숙도，동시검측22례과기임신잉부급50례이혼미잉정상녀성적외주정맥혈조절성T세포비례，분석조절성T세포비례여궁경성숙도적관계。결과잉36주지임산기간잉부조절성T세포비례대우정상미잉녀성；수착잉주적증가조절성T세포비례축점하강，유잉36주시적9.09%하강지임산시적5.48%，궁경Bishop평분축점승고，조절성T세포비례여궁경성숙도성직선반향상관；과기임신잉부조절성T세포비례소우임산산부。결론조절성T세포여분면발동유관。
Objective To investigate the relationship between CD4+CD25+CD127-regulatory T cell and the initial cause of la-bor. Methods In order to analyze the relationship of the proportion of CD4+CD25+CD127-regulatory T cells and initial cause of la-bor,forty pregnant women who were in the gestational weeks of 36,37,38,39 and in labor were enrolled to the study,who were tested the proportion of CD4+CD25+CD127- regulatory T cell and cervical ripeness. Meanwhile,the proportion of CD4 +CD25+CD127-regulatory T cells of 22 prolonged pregnan women and 50 married non-pregnant women were tested. Results The propor-tion of CD4+CD25+CD127-regulatory T cells of pregnant women is higher than that of married non-pregnant women,and the pro-portion gradually declined from 9.09% of the 36th gestational weeks to 5.48% before labor,meanwhile the cervical ripeness rises gradually;the proportion of CD4+CD25+CD127-regulatory T cell have linear inverse correlation with cervical ripeness. At the same time,the proportion of Treg of the post-term pregnant women is higher than that of the women in labor. Conclusion There is a possible association between the proportion of CD4+CD25+CD127-regulatory T and the initial cause of labor.