CAJ | 학술논문

目的：探讨浓缩骨髓干细胞治疗动物骨不连的实验效果。方法制作兔骨不连模型32只，并根据干预方式不同随机均分为两组：干细胞组和内固定植骨术组。定期拍片测量骨折间隙宽度变化（8周、12周）、免疫组化观察。结果两组术后8周、12周X线测定、组织病理切片均形成骨性连接，新骨形成、骨改建及骨髓成熟度指标相当，且两组没有统计学意义（P＞0.05）。结论兔移植自体浓缩的骨髓干细胞参与了骨不连的成骨，有利于骨折的愈合，与自体骨移植效果相当。
목적：탐토농축골수간세포치료동물골불련적실험효과。방법제작토골불련모형32지，병근거간예방식불동수궤균분위량조：간세포조화내고정식골술조。정기박편측량골절간극관도변화（8주、12주）、면역조화관찰。결과량조술후8주、12주X선측정、조직병리절편균형성골성련접，신골형성、골개건급골수성숙도지표상당，차량조몰유통계학의의（P＞0.05）。결론토이식자체농축적골수간세포삼여료골불련적성골，유리우골절적유합，여자체골이식효과상당。
Objective To observe the experiental effect of nonunion treatment with percutaneous autogenous concentrated bone marrow grafting. Methods 32 rabbits were used to make nonunion models,they were grouped randomly into two groups (Bone marrow stem cells group,Internal fixationand grafting group). Periodical standardized radiographs,histology and heal rate after 8weeks and 12weeks were perfoermed. Results The gap changes of bone union at 8weeks and 12weeks after treatment in group A and B,were not statically significant. Conclusion Percutaneous autogenous concentrated bone marrow of the rabbits can induce os-teogenesis in bone nonunion,its efficacy appears to be related to the concentration of bone marrow stem cells in the graft.