中国药师
中國藥師
중국약사
CHINA PHARMACIST
2014年
5期
812-814
,共3页
乌司他丁%生长抑素%急性重症胰腺炎%疗效
烏司他丁%生長抑素%急性重癥胰腺炎%療效
오사타정%생장억소%급성중증이선염%료효
Ulinastatin%Somatostatin%Acute severe pancreatitis%Curative effect
目的：研究乌司他丁联合生长抑素治疗急性重症胰腺炎的临床疗效。方法：130例急性重症胰腺炎患者随机分为两组各65例。在常规治疗基础上,对照组患者给予生长抑素3 mg+0.9%氯化钠注射液250 ml ,ivd,bid,观察组患者在对照组基础上加用乌司他丁10万u+0.9%氯化钠注射液250 ml ,ivd,tid。两组疗程均为10 d。比较治疗后两组患者的临床症状消失时间、呼吸及心率恢复正常时间、住院时间、血尿淀粉酶和临床总有效率。结果：观察组患者的临床症状消失时间、呼吸心率恢复正常时间、住院时间等均明显短于对照组患者(P<0.05),两组血尿淀粉酶恢复时间差异无统计学意义(P>0.05),观察组总有效率为95.38%,对照组总有效率为73.84%,两组比较,差异有统计学意义(P<0.05)。结论：乌司他丁联合生长抑素治疗急性重症胰腺炎疗效显著,可有效改善患者的临床症状,缩短病程,值得临床推广使用。
目的：研究烏司他丁聯閤生長抑素治療急性重癥胰腺炎的臨床療效。方法：130例急性重癥胰腺炎患者隨機分為兩組各65例。在常規治療基礎上,對照組患者給予生長抑素3 mg+0.9%氯化鈉註射液250 ml ,ivd,bid,觀察組患者在對照組基礎上加用烏司他丁10萬u+0.9%氯化鈉註射液250 ml ,ivd,tid。兩組療程均為10 d。比較治療後兩組患者的臨床癥狀消失時間、呼吸及心率恢複正常時間、住院時間、血尿澱粉酶和臨床總有效率。結果：觀察組患者的臨床癥狀消失時間、呼吸心率恢複正常時間、住院時間等均明顯短于對照組患者(P<0.05),兩組血尿澱粉酶恢複時間差異無統計學意義(P>0.05),觀察組總有效率為95.38%,對照組總有效率為73.84%,兩組比較,差異有統計學意義(P<0.05)。結論：烏司他丁聯閤生長抑素治療急性重癥胰腺炎療效顯著,可有效改善患者的臨床癥狀,縮短病程,值得臨床推廣使用。
목적：연구오사타정연합생장억소치료급성중증이선염적림상료효。방법：130례급성중증이선염환자수궤분위량조각65례。재상규치료기출상,대조조환자급여생장억소3 mg+0.9%록화납주사액250 ml ,ivd,bid,관찰조환자재대조조기출상가용오사타정10만u+0.9%록화납주사액250 ml ,ivd,tid。량조료정균위10 d。비교치료후량조환자적림상증상소실시간、호흡급심솔회복정상시간、주원시간、혈뇨정분매화림상총유효솔。결과：관찰조환자적림상증상소실시간、호흡심솔회복정상시간、주원시간등균명현단우대조조환자(P<0.05),량조혈뇨정분매회복시간차이무통계학의의(P>0.05),관찰조총유효솔위95.38%,대조조총유효솔위73.84%,량조비교,차이유통계학의의(P<0.05)。결론：오사타정연합생장억소치료급성중증이선염료효현저,가유효개선환자적림상증상,축단병정,치득림상추엄사용。
Objective:To observe the clinical effect of ulinastatin combined with somatostatin in the treatment of acute severe pan-creatitis. Methods:Totally 130 cases of severe acute pancreatitis patients were randomly divided into two groups with 65 cases in each. The control group was given the routine treatment and 3mg somatostatin in 250ml sodium chloride injections, ivd, bid, and the treatment group was given 10ku ulinastatin in 250ml sodium chloride injections additionally, ivd, bid. After the 10-day treatment, the clinical symptom disappearance time, the recovery time of respiratory and heart rate, length of stay, blood and urine amylase, and clin-ical total effective rate were compared between the two groups. Results:The symptom disappearance time, recovery time of respiratory and heart rate and length of stay in the treatment group were all shorter than those in the control group (P<0. 05). The recovery time of serum and urine amylase in the two groups was without significant difference (P>0. 05). The total effective rate of the treatment group was 95. 38%, while that of the control group was 73. 84% with significant difference (P<0. 05). Conclusion:The application of ulinastatin in the treatment of severe acute pancreatitis shows obviously curative effect, which can effectively improve the clinical symptoms and shorten the course of disease, and is valuable in clinical use.
