CAJ | 학술논문

目的：颅内恶性黑色素瘤是颅内比较罕见的肿瘤，发病率较低。本文探讨颅内黑色素瘤的影像学表现，诊断，病理。方法：回顾性研究我院近20年来16例临床病理诊断为颅内恶性黑色素瘤的患者病例，这些患者均进行过手术治疗，根据其影像学表现、病理诊断及其预后进行细致分析。结果：这16例颅内黑色素瘤患者的症状以颅内占位效应、癫痫与神经系统损害定位症状为主。C T与M RI表现多种多样，差异性较大，M RI具有短T 1，短T 2典型表现有10例患者。病理诊断为上皮样黑色素细胞瘤共有13例，免疫组化特异性标记物S-100（溶解蛋白）和H M B-45（人黑色素相关抗原）可以用来辅助对黑色素瘤的病例诊断。结论：颅内黑色素瘤的临床表现及影像学诊断缺乏特异性，术中所见与病理诊断是其确诊的主要方法。
목적：로내악성흑색소류시로내비교한견적종류，발병솔교저。본문탐토로내흑색소류적영상학표현，진단，병리。방법：회고성연구아원근20년래16례림상병리진단위로내악성흑색소류적환자병례，저사환자균진행과수술치료，근거기영상학표현、병리진단급기예후진행세치분석。결과：저16례로내흑색소류환자적증상이로내점위효응、전간여신경계통손해정위증상위주。C T여M RI표현다충다양，차이성교대，M RI구유단T 1，단T 2전형표현유10례환자。병리진단위상피양흑색소세포류공유13례，면역조화특이성표기물S-100（용해단백）화H M B-45（인흑색소상관항원）가이용래보조대흑색소류적병례진단。결론：로내흑색소류적림상표현급영상학진단결핍특이성，술중소견여병리진단시기학진적주요방법。
Objective :Intracranial malignant melanoma was comparatively rare in intracranial tumors with a lower incidence .This paper discusses the imaging findings ,diagnosis ,pathology .Methods:Retrospective study of nearly 20 years in our hospital 16 patients with pathological diagnosis for patients with intracranial malig-nant melanoma cases ,who underwent surgical treatment ,according to the imaging findings ,pathological diagnosis and prognosis were analyzed carefully .Result :Major manifestations of 16 cases of intracranial malignant melanoma were mass effect ,epilepsy and local symptom .Various signal appearance was found in CT and MRI scan .10 cases were typical in MRI scan .Epithelioid cells were found in 13 cases in pathologic diagnosis .Sensitivity of S-100 and specifically bind to HMB-45 were helpful for diagnosis .Conclusion :Clinical manifestation of intracranial malignant melanoma is not specific ,so most diagnosis depend on intraoperation findings and pathology .