CAJ | 학술논문

目的：探讨缬沙坦对大鼠急性心肌梗死后心室重构和血浆脑钠肽（BNP）、内皮素-1（E T-1）的影响。方法：首先制作大鼠急性心肌梗死模型，然后将手术完成后存活下来的大鼠随机分为三个组，即心肌梗死＋缬沙坦组、心肌梗死组与对照组，使用缬沙坦对缬沙坦组大鼠进行治疗，检测1个月后大鼠体内的血浆脑钠肽（BNP）浓度、内皮素-1（LVESD）浓度和心室重构（LVEDD）情况。结果：与心肌梗死组相比，缬沙坦能显著缩小心室重构指标（LAD、LVESD、LVEDD）并降低了血浆BNP、ET-1水平（P＜0．01），两组间差异有统计学意义。结论：使用缬沙坦治疗大鼠30d ，心肌梗死的大鼠的心室重构得到抑制，血浆脑钠素、内皮素-1水平也明显降低，大鼠心功能得到显著改善。
목적：탐토힐사탄대대서급성심기경사후심실중구화혈장뇌납태（BNP）、내피소-1（E T-1）적영향。방법：수선제작대서급성심기경사모형，연후장수술완성후존활하래적대서수궤분위삼개조，즉심기경사＋힐사탄조、심기경사조여대조조，사용힐사탄대힐사탄조대서진행치료，검측1개월후대서체내적혈장뇌납태（BNP）농도、내피소-1（LVESD）농도화심실중구（LVEDD）정황。결과：여심기경사조상비，힐사탄능현저축소심실중구지표（LAD、LVESD、LVEDD）병강저료혈장BNP、ET-1수평（P＜0．01），량조간차이유통계학의의。결론：사용힐사탄치료대서30d ，심기경사적대서적심실중구득도억제，혈장뇌납소、내피소-1수평야명현강저，대서심공능득도현저개선。
Objective :To observe the effects of the valsartan on serum brain natriuretic peptide (BNP) , serum endothelin-1(ET-1) and heart remodeling after acute myocardial infarction of rats .Methods :90 male wister rats were randomly divided into three groups :① sham group(n= 30);② AMI group(n= 30);③ AMI+ valsartan group(n=30) .Rats in the AMI+valsartan group were given the valsartan .Rat′s serum concentrations of BNP and ET-1 were tested at 30th day after operation while heart remodeling (LAD、LVESD、LVEDD) were measured .Re-sults :Compared with AMI Group ,the blood serum levels of BNP and ET-1 in AMI+valsartan Group rats was smal-ler(P<0 .05) ,and similarly LAD、LVESD、LVEDD in AMI+valsartan Group rats were smaller too .Conclusions :This showed that the valsartan can lessen the increase of BNP and ET-1 blood serum levels and delay the remodeling progress of AMI at 30th day after operation .