CAJ | 학술논문

目的：分析尿路感染大肠埃希菌的耐药特点、种系分型和遗传相关性，并对比其在医院和社区感染中的差异。方法对2010年非重复分离185株尿路感染大肠埃希菌进行敏感性测定、超广谱β-内酰胺酶（ESBLs）筛查、种系分型、同源性及统计学分析。结果细菌对多种药物的耐药率＞49．0％。185株细菌均有很大的遗传多样性，产酶率为78．4％。D型大肠埃希菌最为常见（49．7％），其ESBLs的产生率与头孢噻肟等的耐药性相关（P＜0．05）。上述各因子在医院和社区感染菌株中差异无统计学意义（P＞0．05）。结论本研究尿路感染主要由D型大肠埃希菌引起，这些细菌呈遗传多样性，高产ESBLs，对多种抗菌药物耐药。
목적：분석뇨로감염대장애희균적내약특점、충계분형화유전상관성，병대비기재의원화사구감염중적차이。방법대2010년비중복분리185주뇨로감염대장애희균진행민감성측정、초엄보β-내선알매（ESBLs）사사、충계분형、동원성급통계학분석。결과세균대다충약물적내약솔＞49．0％。185주세균균유흔대적유전다양성，산매솔위78．4％。D형대장애희균최위상견（49．7％），기ESBLs적산생솔여두포새우등적내약성상관（P＜0．05）。상술각인자재의원화사구감염균주중차이무통계학의의（P＞0．05）。결론본연구뇨로감염주요유D형대장애희균인기，저사세균정유전다양성，고산ESBLs，대다충항균약물내약。
Objective To analyze the resistant characterization,phylogenetic grouping and genetic relatedness of Escherichia coli in urinary tract infection,and compare the differences of these factors among the hospital and community infections.Methods A total of 185 non-duplicate Escherichia coli in urinary tract infection were analyzed for sensitivities,extended spectrum beta-lactamases (ESBLs)screening,phylogenetic grouping and genetic relatedness, and the results were analyzed statistically.Results The resistance rates to multiple antibiotics were>49.0%.A total of 185 isolates displayed a high diversity,and the prevalence of ESBLs was 78.4%.Phylogroup D Escherichia coli was the most frequent(49.7%),and the correlation between the production rate of ESBLs and resistance to cefotaxime was observed (P<0.05 ).Additionally,there was no statistical significant on the distribution of the factors between the hospital and community infections (P >0.05 ).Conclusions Urinary tract infection is mainly caused by the phylogroup D Escherichia coli which displays a high diversity of genetic relatedness.High-produced ESBLs are multiple resistant to antibiotics.