CAJ | 학술논문

目的：观察自发高血压大鼠脉压与心室颤动阈值的关系。方法：10周龄雄性自发高血压大鼠共24只，随机分成3组：喂养至18周龄行实验，即18周龄组( n=8)；喂养至24周龄行实验，即24周龄组( n=8)；10周龄组( n=8)；另取8只雄性10周龄Wistar大鼠作为对照组，测量各组大鼠的脉压、心室颤动阈值、心室有效不应期。结果：在自发高血压大鼠中，随着周龄的增长，脉压增大（P<0.05），心室颤动阈值逐渐降低（P<0.05）。心室颤动阈值与脉压呈负相关（r=-0.85,P<0.05）。结论：在自发高血压大鼠中，随着周龄的增长，脉压愈大，心室颤动阈值愈低，易发生恶性室性心律失常，导致心源性猝死。
목적：관찰자발고혈압대서맥압여심실전동역치적관계。방법：10주령웅성자발고혈압대서공24지，수궤분성3조：위양지18주령행실험，즉18주령조( n=8)；위양지24주령행실험，즉24주령조( n=8)；10주령조( n=8)；령취8지웅성10주령Wistar대서작위대조조，측량각조대서적맥압、심실전동역치、심실유효불응기。결과：재자발고혈압대서중，수착주령적증장，맥압증대（P<0.05），심실전동역치축점강저（P<0.05）。심실전동역치여맥압정부상관（r=-0.85,P<0.05）。결론：재자발고혈압대서중，수착주령적증장，맥압유대，심실전동역치유저，역발생악성실성심률실상，도치심원성졸사。
Objective:To observe the relationship between the pulse pressure of spontaneously hypertensive rats and their ventricular fibril ation threshold. Method:Twenty-four ten-weeks-old spontaneously hypertensive male rats were randomly divided into 3 groups:eighteen-weeks-old group (n=8), which were fed to eighteen-weeks-old to do the experiment;Twenty-weeks-old group (n=8), which were fed to twenty-weeks-old to do the experiment;and the 10-weeks-old group (n=8), and eight 10-weeks-old Wistar male rats as control group. Measure the pulse pressure, the ventricular fibril ation threshold and the ventricular effective refractory periods of the rats of every group. Result: With the growth of age, the pulse pressure of the spontaneously hypertensive rats increased (P<0.05), and the ventricular fibril ation threshold decreased gradual y (P<0.05). The ventricular fibril ation threshold and the pulse pressure were of a negative correlation. Conclusion:With the growth of age, the higher the pulse pressure of the spontaneously hypertensive rats, the lower the ventricular fibril ation threshold, and these rats were tender to have malignant ventricular arrhythmia, which lead to sudden death.