CAJ | 학술논문

目的：比较经典型热射病大鼠模型与劳力性热射病大鼠模型的异同。方法雄性SD大鼠随机分为空白对照组、高温高湿安静暴露组(classical heat stroke，CHS)、高温高湿跑台运动组(exertional heat stroke，EHS)，每组10只。监测大鼠肛温(T，℃)、达到发病终点T 42.5℃的时间、发病后大鼠血清肌酸激酶(creatine kinase，CK)水平；观察各组大鼠解剖后主要脏器病理变化(Hematoxylin-eosin染色)。结果大鼠平均发病时间EHS组为(58.333±9.309) min，CHS组为(108.333±23.166) min， EHS组较CHS组发病时间明显加快(P＜0.01)，但两组死亡率差异无统计学意义(P＞0.05)。EHS组与CHS组大鼠发病后血清CK水平的平均值分别为(4444.44±1287.915) U/L、(1208.217±192.802) U/L，EHS组较CHS组血清CK水平明显增高(P＜0.01)；EHS组大鼠各主要器官(小肠、肾脏、骨骼肌等)病理损伤较CHS组大鼠明显加重。结论在动物模型上，劳力性热射病较经典型热射病在发病初期的各器官功能损伤发展更迅速，更严重。
목적：비교경전형열사병대서모형여로력성열사병대서모형적이동。방법웅성SD대서수궤분위공백대조조、고온고습안정폭로조(classical heat stroke，CHS)、고온고습포태운동조(exertional heat stroke，EHS)，매조10지。감측대서항온(T，℃)、체도발병종점T 42.5℃적시간、발병후대서혈청기산격매(creatine kinase，CK)수평；관찰각조대서해부후주요장기병리변화(Hematoxylin-eosin염색)。결과대서평균발병시간EHS조위(58.333±9.309) min，CHS조위(108.333±23.166) min， EHS조교CHS조발병시간명현가쾌(P＜0.01)，단량조사망솔차이무통계학의의(P＞0.05)。EHS조여CHS조대서발병후혈청CK수평적평균치분별위(4444.44±1287.915) U/L、(1208.217±192.802) U/L，EHS조교CHS조혈청CK수평명현증고(P＜0.01)；EHS조대서각주요기관(소장、신장、골격기등)병리손상교CHS조대서명현가중。결론재동물모형상，로력성열사병교경전형열사병재발병초기적각기관공능손상발전경신속，경엄중。
Objective To compare the classic and exertional animal models of heat stroke.Methods Thirty male SD rats were randomly divided into control group, classic heat stroke (CHS) group, and exertional heat stroke (EHS) group (10 in each group). The rectal temperature, its time to reach 42.5℃, and serum creatine kinase (CK) level were measured. Lesions in their major organs were observed with H&E staining.Results The average onset time of heat stroke was significantly shorter whereas the serum CK level was significantly higher in EHS group than in CHS group (58.333±9.309 minvs 108.333±23.166 min, 4 444.44±1 287.915 U/Lvs 1 208.217±192.802 U/L,P<0.01). However, no significant difference was observed in mortality between the two groups (P>0.05). The lesions of major organs (small intestine, kidneys, and skeletal muscle) were significantly severer in EHS group than in CHS group.Conclusion The function of different organs is impaired much rapider and severer in exertional animal model of heat stroke than in classic animal model of heat stroke at its early stage.